Successful treatment of canine sporotrichosis with terbinafine: case reports and literature review

dc.creatorViana, Paula Gonçalves
dc.creatorFigueiredo, Anna Barreto Fernandes
dc.creatorGremião, Isabella Dib Ferreira
dc.creatorMiranda, Luisa Helena Monteiro de
dc.creatorAntonio, Isabela Maria da Silva
dc.creatorBoechat, Jéssica Sepulveda
dc.creatorMachado, Ana Caroline de Sá
dc.creatorOliveira, Manoel Marques Evangelista de
dc.creatorPereira, Sandro Antonio
dc.date2019-06-11T12:40:51Z
dc.date2019-06-11T12:40:51Z
dc.date2018
dc.date.accessioned2023-09-26T20:43:41Z
dc.date.available2023-09-26T20:43:41Z
dc.identifierVIANA,Paula Gonçalves et al. Successful treatment of canine sporotrichosis with terbinafine: case reports and literature review. Mycopathologia, v. 183, p. 471-478, 2018.
dc.identifier0301-486X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33452
dc.identifier10.1007/s11046-017-0225-6
dc.identifier1573-0832
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862780
dc.descriptionSporotrichosis occurs worldwide, and the metropolitan region of Rio de Janeiro, Brazil, is a main endemic area, with a large number of human and animal cases in the last 19 years. This mycosis is more frequently described in cats rather than in dogs. There are a limited number of oral antifungal agents for the treatment of sporotrichosis in animals. In this context, the effectiveness of terbinafine in the treatment of sporotrichosis in humans, as well as the promising results of in vitro susceptibility tests, inspired us to use this drug in the therapy of this mycosis in dogs. We reported for the first time the use of terbinafine in the treatment of two dogs with sporotrichosis caused by Sporothrix brasiliensis. Moreover, we provided an overview of therapeutic features of canine sporotrichosis cases reported since the 1960s. One of the dogs presented the fixed cutaneous form of the disease, while the other patient presented hyperemia of the nasal mucosa and respiratory signs only. Terbinafine showed high antifungal activity in vitro against the canine Sporothrix isolates. The dogs were successfully treated with terbinafine, with remission of all clinical signs initially presented. The current reports indicate that this drug can emerge as a therapeutic option for canine sporotrichosis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag
dc.rightsopen access
dc.subjectSporothrix brasiliensis
dc.subjectDogs
dc.subjectTerbinafine
dc.subjectTherapy
dc.titleSuccessful treatment of canine sporotrichosis with terbinafine: case reports and literature review
dc.typeArticle


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