The Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature

dc.creatorMachado, Bruna Aparecida Souza
dc.creatorHodel, Katharine Valéria Saraiva
dc.creatorBarbosa Júnior, Valdir Gomes
dc.creatorSoares, Milena Botelho Pereira
dc.creatorBadaró, Roberto
dc.date2021-03-04T11:07:27Z
dc.date2021-03-04T11:07:27Z
dc.date2021
dc.date.accessioned2023-09-26T20:43:34Z
dc.date.available2023-09-26T20:43:34Z
dc.identifierMACHADO, Bruna Aparecida Souza et al. The Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature. Viruses, v. 13, p. 1-36, 2021.
dc.identifier1999-4915
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/46251
dc.identifier10.3390/v13010040
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862740
dc.descriptionDiagnostic tests have been considered as the main alternative for the control of coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as a correct diagnosis allows for decision making when facing the disease, particularly as there is a lack of effective therapeutic protocols and vaccines. Thus, in this review, we summarized the main diagnostic approaches currently available for the diagnosis of SARS-CoV-2 infection in humans based on studies available in article databases. The tests can be organized into two main categories: nucleic acid-based tests, recommended for the initial detection of the virus, and serological tests, recommended for assessing the disease progression. The studies have shown that the performance of diagnostic methods depends on different factors, such as the type of samples and the characteristics of each assay. It was identified that the positivity of the tests is mainly related to the onset of symptoms. We also observed that point-of-care diagnoses are considered as one of the main trends in this area, due to the low-cost and simplicity of the assay; however, the analytical performance must be critically analyzed. Thus, the COVID-19 pandemic has highlighted the critical role of diagnostic technologies in the control of infectious diseases.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectDiagnóstico
dc.subjectTeste diagnósticos de rotina
dc.subjectTeste sorologicos
dc.subjectPandemias
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectDiagnostic
dc.subjectMolecular testing
dc.subjectSerology testing
dc.titleThe Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature
dc.typeArticle


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