Factors associated with increased prevalence of human papillomavirus infection in a cohort of HIV-infected brazilian women

dc.creatorGrinsztejn, Beatriz
dc.creatorSantos, Valdiléa Gonçalves Veloso dos
dc.creatorLevi, José Eduardo
dc.creatorVelasque, Luciane
dc.creatorLuz, Paula Mendes
dc.creatorFriedman, Ruth Khalili
dc.creatorAndrade, Angela Cristina
dc.creatorMoreira, Ronaldo Ismerio
dc.creatorRussomano, Fábio Bastos
dc.creatorPilotto, Jose Henrique da Silva
dc.creatorBastos, Francisco Inácio Pinkusfeld Monteiro
dc.creatorPalefsky, Joel
dc.date2013-04-17T13:28:04Z
dc.date2013-04-17T13:28:04Z
dc.date2009
dc.date.accessioned2023-09-26T20:42:54Z
dc.date.available2023-09-26T20:42:54Z
dc.identifierGRINSZTEJN, Beatriz et al. Factors associated with increased prevalence of human papillomavirus infection in a cohort of HIV-infected brazilian women. International Journal of Infectious Diseases, Hamilton, v. 13, n. 1, p. 72-80, Jan. 2009.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6454
dc.identifier10.1016/j.ijid.2008.03.031
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862543
dc.descriptionBrazilian National AIDS Program
dc.descriptionOBJECTIVES: Human papillomavirus (HPV) infection is a major risk factor for cervical disease. Using baseline data from the HIV-infected cohort of Evandro Chagas Clinical Research Institute at Fiocruz, Rio de Janeiro, Brazil, factors associated with an increased prevalence of HPV were assessed. METHODS: Samples from 634 HIV-infected women were tested for the presence of HPV infection using hybrid capture II and polymerase chain reaction. Prevalence ratios (PR) were estimated using Poisson regression analysis with robust variance. RESULTS: The overall prevalence of HPV infection was 48%, of which 94% were infected with a high-risk HPV. In multivariate analysis, factors independently associated with infection with high-risk HPV type were: younger age (<30 years of age; PR 1.5, 95% confidence interval (CI) 1.1-2.1), current or prior drug use (PR 1.3, 95% CI 1.0-1.6), self-reported history of HPV infection (PR 1.2, 95% CI 0.96-1.6), condom use in the last sexual intercourse (PR 1.3, 95% CI 1.1-1.7), and nadir CD4+ T-cell count <100cells/mm(3) (PR 1.6, 95% CI 1.2-2.1). CONCLUSIONS: The estimated prevalence of high-risk HPV-infection among HIV-infected women from Rio de Janeiro, Brazil, was high. Close monitoring of HPV-related effects is warranted in all HIV-infected women, in particular those of younger age and advanced immunosuppression.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectHuman Papillomavirus
dc.subjectHuman Immunodeficiency Virus
dc.subjectEvandro Chagas Research Institute Cohort
dc.subjectPrevalence Ratio
dc.subjectBrazil
dc.subjectInfecções por HIV - complicações
dc.subjectPapillomaviridae - classificação
dc.subjectInfecções por Papillomavirus - complicações
dc.titleFactors associated with increased prevalence of human papillomavirus infection in a cohort of HIV-infected brazilian women
dc.typeArticle


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