Outbreaks, persistence, and high mortality rates of multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions

dc.creatorGomes, Marisa Zenaide Ribeiro
dc.creatorMachado, Carolina Romero
dc.creatorConceição, Magda de Souza da
dc.creatorOrtega, Jois Alves
dc.creatorNeves, Sonia Maria Ferraz M.
dc.creatorLourenço, Maria Cristina da Silva
dc.creatorAsensi, Marise Dutra
dc.date2018-11-26T19:54:31Z
dc.date2018-11-26T19:54:31Z
dc.date2011
dc.date.accessioned2023-09-26T20:42:10Z
dc.date.available2023-09-26T20:42:10Z
dc.identifierGOMES, Marisa Zenaide Ribeiro et al. Outbreaks, persistence, and high mortality rates of multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions. Brazilian Journal of Infectious Diseases, v. 15, n. 4, p. 312-322, July/Aug. 2011.
dc.identifier1413-8670
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/30212
dc.identifier10.1016/s1413-8670(11)70198-2
dc.identifier1678-4391
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862312
dc.descriptionIntroduction: Authors have reported increased incidence of multiresistant Pseudomonas aeruginosa (MR-PA) infections worldwide over the last decade. Researchers have proposed multifaceted approaches to control MR-PA infections, but none have been reported in the acquired immunodeficiency syndrome (AIDS) setting. Objective and Methods: Herein we report the impact of a multifaceted intervention for controlling MR-PA over five years in a hospital with AIDS-predominant admissions and describe the clinical characteristics of MR-PA infection in our patient population. The clinical outcomes of infected patients and molecular characteristics of the isolated strains were used as tools for controlling MR-PA infection rates. Results: Significant temporary decrease of new infections was achieved after intervention, although a high level of diagnostic suspicion of nosocomial infection was maintained. We obtained 35 P. aeruginosa isolates with multiresistant profiles from 13 infected and 3 colonized patients and 2 environmental samples. Most of the patients (94%) were immunocompromised with AIDS (n = 10) or HTLV-1 infections (n = 5). Of the followed patients, 67% had persistent and/or recurrent infections, and 92% died. We observed differences in the antibiotic-resistance pattern of MR-PA infection/colonization during two outbreaks, although the genetic profiles of the tested strains were identical. Conclusions: Therefore, we concluded that early multidisciplinary interventions are essential for reducing the burden caused by this microorganism in patients with AIDS. Prolonged or suppressive antibiotic-based therapy should be considered for MR-PA infections in patients with AIDS because of the persistence characteristic of MR-PA in these patients.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectPseudomonas aeruginosa
dc.subjectSurtos de doenças
dc.subjectControle de infecção
dc.subjectEpidemiologia molecular
dc.subjectSíndrome da Imunodeficiência Adquirida
dc.subjectPseudomonas aeruginosa
dc.subjectDisease outbreaks
dc.subjectInfection control
dc.subjectMolecular epidemiology
dc.subjectAcquired immunodeficiency syndrome
dc.titleOutbreaks, persistence, and high mortality rates of multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions
dc.typeArticle


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