Parasitological and morphological study of Schistosoma mansoni and diabetes mellitus in mice

dc.creatorHulstijn, Maarten
dc.creatorBarros, Lucas de Andrade
dc.creatorNeves, Renata Heisler
dc.creatorMoura, Egberto Gaspar de
dc.creatorSilva, José Roberto Machado
dc.date2017-10-24T15:19:53Z
dc.date2017-10-24T15:19:53Z
dc.date2011
dc.date.accessioned2023-09-26T20:42:07Z
dc.date.available2023-09-26T20:42:07Z
dc.identifierHULSTIJN, Maarten; et al. Parasitological and morphological study of Schistosoma mansoni and diabetes mellitus in mice. Experimental Parasitology, v.129, p.42–47, 2011.
dc.identifier0014-4894
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/22927
dc.identifier10.1016/j.exppara.2011.05.017
dc.identifier1090-2449
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862297
dc.descriptionSchistosomes are blood-dwelling flukes which are highly dependent on the host metabolism. The aim of this study was to investigate possible relationship between streptozotocin-induced diabetes and the outcome of acute murine schistosomiasis mansoni. Male and female SW mice were treated by a single intraperitoneally injected dose of streptozotocin (180 mg/kg). Seven days after induction, both control and diabetic animals were infected with 70 Schistosoma mansoni cercariae (BH strain). Diabetics and their controls were weighed 45 days after birth and for the last time prior to killing. Susceptibility to infection was evaluated twice a week by quantifying fecal egg excretion 7-9 weeks post-infection by the Kato-Katz' thick smear method. Mice were euthanized the day after the last fecal examination was performed. Adult worms were recovered from the portal system and mesenteric veins, whereas liver and intestine were removed for enumeration of egg load. No differences in worm length or in measurements of the reproductive organs, tegument, and suckers were detected. Also oviposition was unaffected as the total number of eggs per female worm from the liver, the small and the large intestine was the same in both groups. An oogram evaluation revealed a lower percentage of mature (23.0% vs. 40.7%) and a higher percentage of immature (69.1% vs. 51.7%) eggs in the small intestine of the diabetic mice. We suggest that principally a hampered egg passage through the intestine tissue caused this reduction and that probably both the eggs and the impaired host response play a role.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectSchistosoma mansoni
dc.subjectDiabetes mellitus
dc.subjectRelação hospedeiro-parasita
dc.subjectSchistosoma mansoni
dc.subjectDiabetes mellitus
dc.subjectHost–parasite relation
dc.titleParasitological and morphological study of Schistosoma mansoni and diabetes mellitus in mice
dc.typeArticle


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