Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review

dc.creatorSilva, Taylon Felipe
dc.creatorTomiotto-Pellissier, Fernanda
dc.creatorPasquali, Aline Kuhn Sbruzzi
dc.creatorPinto-Ferreira, Fernanda
dc.creatorPavanelli, Wander Rogério
dc.creatorConchon-Costa, Ivete
dc.creatorNavarro, Italmar Teodorico
dc.creatorCaldart, Eloiza Teles
dc.date2021-11-25T17:56:30Z
dc.date2021-11-25T17:56:30Z
dc.date2021
dc.date.accessioned2023-09-26T20:41:15Z
dc.date.available2023-09-26T20:41:15Z
dc.identifierSILVA, Taylon Felipe et al. Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review. Acta Tropica. v. 221, n. 106018, p. 1–8, 2021.
dc.identifier0001-706X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/50065
dc.identifier10.1016/j.actatropica.2021.106018
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862018
dc.descriptionLeishmania (Leishmania) amazonensis is an important etiological agent of American cutaneous leishmaniasis (ACL) in Brazil. The species causes a large spectrum of clinical manifestations in humans and dogs, ranging from cutaneous, cutaneous diffuse, mucocutaneous, and visceral involvement, however, the factors that drive the development of different disease forms by the same species are not yet fully known. In the present work, it was systematically reviewed the studies addressing phenotypic and genotypic characteristics of Leishmania (L.) amazonensis isolates causing cutaneous and visceral clinical frames in humans and dogs, comparing the results observed. For this, four research databases were searched for the following keywords: (Leishmania amazonensis AND visceral leishmaniasis) AND (tropism OR virulence OR visceralization OR adaptations OR mutation OR clinical presentation OR resistance OR survival OR wide spectrum). The results revealed that the complexity disease seems to involve the combination of genetic factors of the parasite (as modifications in molecules related to the virulence and metabolism) and also of the host’s immune background and status. Nonetheless, the exact mechanism that leads to different clinical manifestations between strains of the same species is still uncertain and future studies must be developed to better elucidate this phenomenon.
dc.formatapplication/pdf
dc.languagepor
dc.publisherActa Tropica
dc.rightsopen access
dc.subjectLeishmania amazonensis
dc.subjectLeishmaniasis, Cutaneous
dc.subjectLeishmaniasis, Visceral
dc.subjectVirulence
dc.subjectLeishmaniasis Cutánea
dc.subjectLeishmaniasis Visceral
dc.subjectVirulencia
dc.subjectLeishmaniose cutanée
dc.subjectLeishmaniose viscérale
dc.subjectVirulence
dc.subjectLeishmaniose Cutânea
dc.subjectLeishmaniose Visceral
dc.subjectVirulência
dc.titlePhenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review
dc.typeArticle


Este ítem pertenece a la siguiente institución