Calcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents

dc.creatorOliveira, Tiê Menezes
dc.creatorBerti, Fernanda Costa Brandão
dc.creatorGasoto, Sidney Carlos
dc.creatorSchneider Jr., Bertoldo
dc.creatorStimamiglio, Marco Augusto
dc.creatorBerti, Lucas Freitas
dc.date2022-03-25T13:42:06Z
dc.date2022-03-25T13:42:06Z
dc.date2021
dc.date.accessioned2023-09-26T20:41:15Z
dc.date.available2023-09-26T20:41:15Z
dc.identifierOLIVEIRA, Tiê Menezes et al. Calcium phosphate-based bioceramics in the treatment of Osteosarcoma: drug delivery composites and magnetic hyperthermia agents. Frontiers in Medical Technology, v. 3, n. 700266, p. 1–12, 2021.
dc.identifier2235-2988
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51871
dc.identifier10.3389/fmedt.2021.700266
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862017
dc.descriptionThe use of biomaterials in medicine is not recent, and in the last few decades, the research and development of biocompatible materials had emerged. Hydroxyapatite (HAp), a calcium phosphate that constitutes a large part of the inorganic composition of human bones and teeth, has been used as an interesting bioceramic material. Among its applications, HAp has been used to carry antitumor drugs, such as doxorubicin, cisplatin, and gemcitabine. Such HAp-based composites have an essential role in anticancer drug delivery systems, including the treatment of osteosarcoma. In addition, the association of this bioceramic with magnetic nanoparticles (MNPs) has also been used as an effective agent of local magnetic hyperthermia. Further, the combined approach of the aforementioned techniques (HAp scaffolds combined with anti-tumor drugs and MNPs) is also an attractive therapeutical alternative. Considering the promising role of the use of bioceramics in modern medicine, we proposed this review, presenting an updated perspective on the use of HAp in the treatment of cancer, especially osteosarcoma. Finally, after giving the current progress in this field, we highlight the urgent need for efforts to provide a better understanding of their potential applications.
dc.formatapplication/pdf
dc.languagepor
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectBiocerâmica
dc.subjectDurapatite
dc.subjectBiocompatible Materials
dc.subjectDrug Delivery Systems
dc.subjectHyperthermia
dc.subjectOsteosarcoma
dc.subjectDurapatita
dc.subjectMateriales Biocompatibles
dc.subjectSistemas de Liberación de Medicamentos
dc.subjectHipertermia
dc.subjectOsteosarcoma
dc.subjectDurapatite
dc.subjectMatériaux biocompatibles
dc.subjectSystèmes de délivrance de médicaments
dc.subjectHyperthermie
dc.subjectOstéosarcome
dc.subjectHidroxiapatita
dc.subjectMateriais Biocompatíveis
dc.subjectSistemas de Liberação de Medicamentos
dc.subjectHipertermia
dc.subjectOsteossarcoma
dc.titleCalcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents
dc.typeArticle


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