Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy

dc.creatorCalvo, Thyago Leal
dc.creatorMoraes, Milton Ozório
dc.date2020-12-21T20:16:21Z
dc.date2020-12-21T20:16:21Z
dc.date2019
dc.date.accessioned2023-09-26T20:40:54Z
dc.date.available2023-09-26T20:40:54Z
dc.identifierCALVO, Thiago Leal; MORAES, Milton Ozório. Reanalysis and integration of public microarray datasets reveals novel host genes modulated in Leprosy. bioRxiv, p. 1-23, 2019.
dc.identifier1617-4615
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45064
dc.identifier10.1101/824805
dc.identifier1617-4623
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861902
dc.descriptionLeprosy is an insidious disease caused primarily by mycobacteria. The difficulties in culturing this slow-growing bacteria together with the chronic progression of the disease have hampered the development of accurate methods for diagnosis. Host gene expression profiling is an important tool to assess overall tissue activity, whether in health or disease conditions. High-throughput gene expression experiments have become popular over the last decade or so, and public databases have been created to easily store and retrieve these data. This has enabled researchers to reuse and reanalyze existing datasets with the aim of generating novel and or more robust information. In this work, after a systematic search, nine microarray datasets evaluating host gene expression in leprosy were reanalyzed and the information was integrated to strengthen evidence of differential expression for several genes.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsopen access
dc.subjectReanálise
dc.subjectDados públicos
dc.subjectMicroarray
dc.subjectNovos genes hospedeiros
dc.subjectHanseníase
dc.subjectLeprosy
dc.subjectReanalysis
dc.subjectPublic Datasets
dc.subjectMicroarray
dc.subjectNovel Host Genes
dc.titleReanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy
dc.typePreprint


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