Morphological and immuno-histochemical characterization of five phyllodes mammary gland tumors in dogs

dc.creatorAraújo, Marina Rios de
dc.creatorDamasceno, Karine Araujo
dc.creatorGamba, Conrado de Oliveira
dc.creatorCampos, Cecília Bonolo
dc.creatorCampos, Liliane Cunha
dc.creatorReis, Diego Carlos dos
dc.creatorSouza, Cristina Maria de
dc.creatorCassali, Geovanni Dantas
dc.date2018-06-14T16:26:55Z
dc.date2018-06-14T16:26:55Z
dc.date2014
dc.date.accessioned2023-09-26T20:40:49Z
dc.date.available2023-09-26T20:40:49Z
dc.identifierARAÚJO0, M. R. et al. Morphological and immuno-histochemical characterization of five phyllodes mammary gland tumors in dogs. Online Journal of Veterinary Research: OJVR, v. 18, n. 8, p. 688-695, 2014.
dc.identifier1328-925X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26891
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861877
dc.descriptionDamasceno, Karine Araújo. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo a Pesquisa de Minas Gerais (FAPEMIG), Brazil.
dc.descriptionIn bitches, mammary tumors represent 52% of all neoplasms. The phyllodes tumor is a rare fibro-epithelial neoplasm found in humans characterized by epithelial and mesenchymal (stromal) cell proliferation creating elaborate leaf-like structures. Morphological and immune-histochemical characteristics in 5 canine phyllodes tumors are described. Four benign and one malignant phyllodes tumors were diagnosed. Epithelial and stromal tumor cells were positive for cytokeratin AE1AE3 and vimentin, respectively, and all were positive for estrogen and progesterone receptors. Benign tumors were negative for p63 whereas the malignant tumor was positive for p63. Cell proliferation index was <1% in benign tumors tissue but 69.5% in the malignant one. All tumors were negative for c-KIT. The morphological and immune-phenotypical aspects observed in this study suggest similarities between phyllodes tumors diagnosed in women and in bitches. However, new studies are necessary to enhance knowledge regarding the biological behavior of these neoplasms.
dc.formatapplication/pdf
dc.languageeng
dc.publisherDesconhecida
dc.rightsopen access
dc.subjectCachorro
dc.subjectImuno-histoquímica
dc.subjectNeoplasia mamária
dc.subjectTumor phyllodes
dc.subjectDog
dc.subjectImmunohistochemistry
dc.subjectMammary neoplasm
dc.subjectPhyllodes tumor
dc.titleMorphological and immuno-histochemical characterization of five phyllodes mammary gland tumors in dogs
dc.typeArticle


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