Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis

dc.creatorPaixão, Enny S.
dc.creatorRodrigues, Moreno S.
dc.creatorCardim, Luciana L.
dc.creatorOliveira, Juliane F.
dc.creatorL. C., Catharina
dc.creatorCosta, Maria da Conceição N.
dc.creatorBarreto, Maurício Lima
dc.creatorRodrigues, Laura C.
dc.creatorSmeeth, Liam
dc.creatorAndrade, Roberto F. S.
dc.creatorOliveira, Wanderson K.
dc.creatorTeixeira, Maria da Glória Lima Cruz
dc.date2020-01-31T13:49:02Z
dc.date2020-01-31T13:49:02Z
dc.date2019
dc.date.accessioned2023-09-26T20:40:07Z
dc.date.available2023-09-26T20:40:07Z
dc.identifierPAIXÃO, Enny S. et al. Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis. PLOS Neglected Tropical Diseases, p. 1-12, Sept. 23 2019.
dc.identifier1935-2727
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39660
dc.identifier10.1371/journal.pntd.0007721
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861657
dc.descriptionWellcome Trust (grant number 213589/Z/18/Z). The funders had no role in study design, analysis, decision to publish or preparation of the manuscript.
dc.descriptionThis study aimed to assess the impact of the Zika epidemic on the registration of birth defects in Brazil. We used an interrupted time series analysis design to identify changes in the trends in the registration of congenital anomalies. We obtained monthly data from Brazilian Live Birth Information System and used two outcome definitions: 1) rate of congenital malformation of the brain and eye (likely to be affected by Zika and its complications) 2) rate of congenital malformation not related to the brain or eye unlikely to be causally affected by Zika. The period between maternal infection with Zika and diagnosis of congenital abnormality attributable to the infection is around six months. We therefore used September 2015 as the interruption point in the time series, six months following March 2015 when cases of Zika started to increase. For the purposes of this analysis, we considered the period from January 2010 to September 2015 to be "pre-Zika event," and the period from just after September 2015 to December 2017 to be "post-Zika event." We found that immediately after the interruption point, there was a great increase in the notification rate of congenital anomalies of 14.9/10,000 live births in the brain and eye group and of 5.2/10,000 live births in the group not related with brain or eye malformations. This increase in reporting was in all regions of the country (except in the South) and especially in the Northeast. In the period "post-Zika event", unlike the brain and eye group which showed a monthly decrease, the group without brain or eye malformations showed a slow but significant increase (relative to the pre-Zika trend) of 0.2/10,000 live births. These findings suggest an overall improvement in the registration of birth malformations, including malformations that were not attributed to Zika, during and after the Zika epidemic.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectZika vírus
dc.subjectZika vírus infecção
dc.subjectGravidez
dc.subjectEpidemia
dc.subjectHumanos
dc.subjectBrasil
dc.subjectZika virus
dc.subjectZika virus infection
dc.subjectPregnancy
dc.subjectEpidemics
dc.subjectHuman
dc.subjectBrazil
dc.titleImpact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis
dc.typeArticle


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