Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection.

dc.creatorPereira, Fernanda Albuquerque
dc.creatorSilva, Naize Nara Pinheiro da
dc.creatorRodart, Itatiana Ferreira
dc.creatorCarmo, Theomira Mauadie de Azevedo
dc.creatorLemaire, Denise Carneiro
dc.creatorReis, Mitermayer Galvão dos
dc.date2014-04-15T12:55:24Z
dc.date2014-04-15T12:55:24Z
dc.date2008
dc.date.accessioned2023-09-26T20:40:06Z
dc.date.available2023-09-26T20:40:06Z
dc.identifierPEREIRA, F. A. et al. Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. Journal of Medical Virology, v. 80, n. 1, p. 58-64, 2008.
dc.identifier0146-6615
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7522
dc.identifier10.1002/jmv.21011
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861652
dc.descriptionCytokines play a key role in the regulation of immune responses. In hepatitis C virus infection (HCV), the production of abnormal cytokine levels appears to contribute to the progression of the disease, viral persistence, and affects response to therapy. Cytokine genes are polymorphic at specific sites, and certain polymorphisms located within coding/regulatory regions have been shown to affect the overall expression and secretion of cytokines. The aim of the present study was to identify potential markers of cytokines genes associated with the susceptibility to HCV infection. The cohort was composed of 128 individuals infected by HCV and 94 healthy controls. Genotyping was carried out by PCR-SSP. The distributions of the following polymorphisms were compared in these groups: TNF-alpha (-308G/A [rs1800629]), TGF-beta1 (codon 10 T/C [rs1982073], codon 25 G/C [rs1800471]), IL-10 (-1082 A/G [rs 1800896]; -819T/C [rs1800871]; -592A/C [rs 1800872]), IL-6 (-174G/C [rs1800795]), and IFN-gamma (+874T/A [rs2430561]). This study demonstrated a statistically significant difference in the frequency of TGF-beta1 codon 25 polymorphism between healthy subjects and those infected with HCV. No associations were observed between polymorphisms of TNF-alpha, IFN-gamma, IL-10, TGF-beta1 codon 10, and IL-6 and HCV infection. These findings suggest that TGF-beta1 codon 25 polymorphism could be a host genetic factor associated with susceptibility to HCV infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley-Liss, INC
dc.rightsopen access
dc.subjectHepatitis C
dc.subjectGenes
dc.subjectCytokines
dc.subjectPolymorphism (genetics)
dc.subjectCitocinas/genética
dc.subjectPredisposição Genética para Doença
dc.subjectPredisposição Genética para Doença
dc.subjectPolimorfismo Genético/genética
dc.subjectFator de Crescimento Transformador beta1/genética
dc.subjectAdulto
dc.subjectMarcadores Biológicos
dc.subjectCódon/genética
dc.subjectEstudos de Coortes
dc.subjectFeminino
dc.subjectPredisposição Genética para Doença/epidemiologia
dc.subjectGenótipo
dc.subjectHepacivirus/química
dc.subjectHepacivirus/genética
dc.subjectHepatite C/fisiopatologia
dc.subjectHepatite C/virologia
dc.subjectHumanos
dc.subjectMasculino
dc.subjectMeia-Idade
dc.titleAssociation of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection.
dc.typeArticle


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