Cytotoxicity of Piperamides Towards Aedes aegypti (Diptera: Culicidae)

dc.creatorMaleck, Marise
dc.creatorFerreira, Bruna
dc.creatorSantos-Mallet, Jacenir R.
dc.creatorGuimarães, Anthony
dc.creatorKato, Massuo
dc.date2015-06-08T14:01:48Z
dc.date2015-06-08T14:01:48Z
dc.date2014
dc.date.accessioned2023-09-26T20:39:37Z
dc.date.available2023-09-26T20:39:37Z
dc.identifierMALECK, Marise et al. Cytotoxicity of Piperamides Towards Aedes aegypti (Diptera: Culicidae). Journal of Medical Entomology, v.51, n.2, p.458-463. 2014.
dc.identifier1938-2928
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10685
dc.identifier10.1603/ME13069
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861505
dc.descriptionThe effectiveness of the amides piplartine and piperlonguminine isolated from Piper species for controlling L3 and L4 of Aedes aegypti (L.) was assessed through bioassays at concentrations ranging from 1 to 300 g/ml. Piplartine reduced the mosquito development period and caused larval mortality only at concentrations 100 g/ml, whereas piperlonguminine resulted in an extended period of mosquito development (10 g/ml) and caused 100% larval mortality (30 g/ml) within 24 h. The toxicity and cytotoxic effects of piperlonguminine on epithelial cells of the digestive system of Ae. aegypti were viewed using transmission electron microscopy, which indicated vacuolization of cytoplasm, mitochondrial swelling and leaking of nuclear material. Piperlonguminine was the more effective amide, showing toxic activity with LD50 of 12 g/ml against the larvae of Ae. aegypti.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioOne
dc.rightsopen access
dc.subjectCitotoxicidade
dc.subjectAedes
dc.subjectCytotoxicity
dc.subjectCulicidae
dc.subjectLarvicide
dc.subjectPiperamide
dc.subjectAedes aegypti
dc.subjectCulicidae
dc.titleCytotoxicity of Piperamides Towards Aedes aegypti (Diptera: Culicidae)
dc.typeArticle


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