Otro
Sister-chromatid exchanges in β-thalassaemic patients under conditions of in vivo and in vitro depletion of folic acid
Registration in:
Mutation Research - Mutation Research Letters, v. 282, n. 3, p. 213-217, 1992.
0165-7992
10.1016/0165-7992(92)90098-3
2-s2.0-0026740527
Author
Silva, A. E.
Manzato, A. J.
Varella-Garcia, M.
Abstract
In order to investigate the effect of folate depletion, lymphocyte sister-chromatid exchange (SCE) rates were compared among homozygous β-thalassaemic patients with low folic acid levels, heterozygous β-thalassaemic patients with normal folate levels and healthy persons with normal haemoglobin, in cultures with both normal and depleted folate conditions. Significantly higher SCE rates were found in homozygous patients in all assays, but the in vitro folate depletion did not induce an increase in SCE frequency in any group.