Mosquito genomes are frequently invaded by transposable elements through horizontal transfer

dc.creatorMelo, Elverson Soares de
dc.creatorWallau, Gabriel Luz
dc.date2021-04-15T15:41:58Z
dc.date2021-04-15T15:41:58Z
dc.date2020
dc.date.accessioned2023-09-26T20:39:29Z
dc.date.available2023-09-26T20:39:29Z
dc.identifierMELO, E. S. de. et al. Mosquito genomes are frequently invaded by transposable elements through horizontal transfer. PLoS Genet, v. 16(11), p. 1 – 26, 30 nov. 2020.
dc.identifier1553-7390
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/46717
dc.identifier10.1371/journal.pgen.1008946
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861463
dc.descriptionTransposable elements (TEs) are mobile genetic elements that parasitize basically all eukaryotic species genomes. Due to their complexity, an in-depth TE characterization is only available for a handful of model organisms. In the present study, we performed a de novo and homology-based characterization of TEs in the genomes of 24 mosquito species and investigated their mode of inheritance. More than 40% of the genome of Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus is composed of TEs, while it varied substantially among Anopheles species (0.13%-19.55%). Class I TEs are the most abundant among mosquitoes and at least 24 TE superfamilies were found. Interestingly, TEs have been extensively exchanged by horizontal transfer (172 TE families of 16 different superfamilies) among mosquitoes in the last 30 million years. Horizontally transferred TEs represents around 7% of the genome in Aedes species and a small fraction in Anopheles genomes. Most of these horizontally transferred TEs are from the three ubiquitous LTR superfamilies: Gypsy, Bel-Pao and Copia. Searching more than 32,000 genomes, we also uncovered transfers between mosquitoes and two different Phyla-Cnidaria and Nematoda-and two subphyla-Chelicerata and Crustacea, identifying a vector, the worm Wuchereria bancrofti, that enabled the horizontal spread of a Tc1-mariner element among various Anopheles species. These data also allowed us to reconstruct the horizontal transfer network of this TE involving more than 40 species. In summary, our results suggest that TEs are frequently exchanged by horizontal transfers among mosquitoes, influencing mosquito's genome size and variability.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectAnimals
dc.subjectAnopheles / genetics
dc.subjectCulicidae / genetics
dc.subjectDNA Transposable Elements / genetics
dc.subjectDatabases, Genetic
dc.subjectEvolution, Molecular
dc.subjectGene Transfer, Horizontal / genetics
dc.subjectGenome / genetics
dc.subjectMosquito Vectors / genetics
dc.subjectPhylogeny
dc.subjectRetroelements
dc.subjectAnimais
dc.subjectAnopheles / genética
dc.subjectCulicidae / genética
dc.subjectElementos de DNA Transponíveis / genética
dc.subjectBases de Dados Genéticas
dc.subjectEvolução Molecular
dc.subjectTransferência Genética Horizontal / genética
dc.subjectGenoma / genética
dc.subjectMosquitos Vetores / genética
dc.subjectFilogenia
dc.subjectRetroelements
dc.titleMosquito genomes are frequently invaded by transposable elements through horizontal transfer
dc.typeArticle


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