Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study.

dc.creatorGuimarães, Adriana Gibara
dc.creatorScotti, Luciana
dc.creatorScotti, Marcus Tullius
dc.creatorMendonça Júnior, Francisco Jaime Bezerra
dc.creatorMelo, Nayara Stephanie Resende
dc.creatorAlves, Rafael dos Santos
dc.creatorDe Lucca Júnior, Waldecy
dc.creatorBezerra, Daniel Pereira
dc.creatorGelain, Daniel Pens
dc.creatorQuintans Júnior, Lucindo José
dc.date2015-05-20T14:28:54Z
dc.date2015-05-20T14:28:54Z
dc.date2014
dc.date.accessioned2023-09-26T20:39:24Z
dc.date.available2023-09-26T20:39:24Z
dc.identifierGUIMARÃES, A. G. et al. Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study. Life Science, v. 116, n. 1, p. 8-15, 2014.
dc.identifier1879-0631
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10438
dc.identifierdx.doi.org/10.1016/j.lfs.2014.08.020
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861437
dc.descriptionAIMS: The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice. MAIN METHODS: Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 24h after injection of the sarcoma cells in the hind paw (s.c.). Mice were evaluated for mechanical sensitivity (von Frey), spontaneous and palpation-induced nociception, limb use and tumor growth on alternate days. CARV effects on the central nervous system were evaluated through immunofluorescence for Fos protein. Molecular docking studies also were performed to evaluate intermolecular interactions of the carvacrol and muscimol, as ligands of interleukin-10 and GABAA receptors. KEY FINDINGS: CARV was able to significantly reduce mechanical hyperalgesia and spontaneous and palpation-induced nociception, improve use paw, decrease the number of positively marked neurons in lumbar spinal cord and activate periaqueductal gray, nucleus raphe magnus and locus coeruleus. CARV also caused significant decreased tumor growth. Docking studies showed favorable interaction overlay of the CARV with IL-10 and GABAA. SIGNIFICANCE: Together, these results demonstrated that CARV may be an interesting option for the development of new analgesic drugs for the management of cancer pain
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectCancer pain
dc.subjectHyperalgesia
dc.subjectNociception
dc.subjectMonoterpene
dc.subjectCarvacrol
dc.subjectAnalgésicos/farmacologia
dc.subjectHiperalgesia/quimioterapia
dc.subjectMonoterpenos/farmacologia
dc.subjectDor/quimioterapia
dc.subjectSarcoma 180/complicações
dc.subjectAnalgésicos/administração & dosagem
dc.subjectAnimais
dc.subjectRelação Dose-Resposta a Droga
dc.subjectHiperalgesia/etiologia
dc.subjectInterleucina-10/metabolismo
dc.subjectMasculino
dc.subjectCamundongos Endogâmicos C57BL
dc.subjectSimulação de Acoplamento Molecular
dc.subjectMonoterpenos/administração & dosagem
dc.subjectMuscimol/farmacologia
dc.subjectSubstância Cinzenta Periaquedutal/efeitos de drogas
dc.subjectReceptores de GABA-A/metabolismo
dc.subjectSarcoma 180/patologia
dc.subjectMedula Espinal/efeitos de drogas
dc.titleEvidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study.
dc.typeArticle


Este ítem pertenece a la siguiente institución