The effect of bovine interferon-alpha I1 on pregnancy rate in heifers.

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBarros, C. M.
dc.creatorNewton, G. R.
dc.creatorThatcher, W. W.
dc.creatorDrost, M.
dc.creatorPlante, C.
dc.creatorHansen, P. J.
dc.date2014-05-27T11:17:28Z
dc.date2016-10-25T18:12:55Z
dc.date2014-05-27T11:17:28Z
dc.date2016-10-25T18:12:55Z
dc.date1992-05-01
dc.date.accessioned2017-04-06T00:43:55Z
dc.date.available2017-04-06T00:43:55Z
dc.identifierJournal of animal science, v. 70, n. 5, p. 1471-1477, 1992.
dc.identifier0021-8812
dc.identifierhttp://hdl.handle.net/11449/64233
dc.identifierhttp://acervodigital.unesp.br/handle/11449/64233
dc.identifier2-s2.0-0026859979.pdf
dc.identifier2-s2.0-0026859979
dc.identifierhttp://www.journalofanimalscience.org/content/70/5/1471.long
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886135
dc.descriptionBovine interferon-alpha I1 (bIFN-alpha) may be useful for enhancing fertility in sheep and cattle because it has extensive sequence homology with ovine and bovine trophoblast protein-1 and, like those proteins, extends corpus luteum lifespan. To test the effectiveness of bIFN-alpha to enhance fertility, several experiments were performed in which inseminated heifers were given i.m. injections of bIFN-alpha approximately at the time of embryo-mediated signals that result in maintenance of the corpus luteum. In Exp. 1, heifers given 20 mg of bIFN-alpha daily from d 14 to 17 tended (P less than .07) to have lower pregnancy rates at d 110 to 112 of gestation (36/75; 48% vs 43/72; 60%). Similar results were obtained in Exp. 2 when heifers received a single injection of 40 mg of bIFN-alpha or placebo at d 13 after estrus; pregnancy rates at d 42 were 39/104 (38%) for bIFN-alpha and 47/98 (48%) for placebo. In Exp. 3, heifers were given gradually increasing doses of bIFN-alpha or placebo from d 11 to 19, because such a regimen had been shown to reduce the number of heifers experiencing hyperthermia after bIFN-alpha injection. Pregnancy rates were 42/95 (44%) for bIFN-alpha and 62/111 (56%) for placebo. Across all three experiments, pregnancy rates were lower (P less than .01) for heifers treated with bIFN-alpha (117/274; 43%) than for heifers treated with placebo (152/281; 54%). In conclusion, these results demonstrate that, under the administration systems used, bIFN-alpha does not increase pregnancy rate, but rather tends to reduce it.
dc.languageeng
dc.relationJournal of Animal Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectrecombinant interferon
dc.subjectanimal
dc.subjectbody temperature
dc.subjectcattle
dc.subjectdouble blind procedure
dc.subjectdrug effect
dc.subjectestrus
dc.subjectfemale
dc.subjectfertility
dc.subjectfertilization
dc.subjectphysiology
dc.subjectpregnancy
dc.subjectrandomization
dc.subjectAnimal
dc.subjectBody Temperature
dc.subjectCattle
dc.subjectDouble-Blind Method
dc.subjectEstrus
dc.subjectFemale
dc.subjectFertility
dc.subjectFertilization
dc.subjectInterferon Type I, Recombinant
dc.subjectPregnancy
dc.subjectRandom Allocation
dc.subjectSupport, Non-U.S. Gov't
dc.subjectSupport, U.S. Gov't, Non-P.H.S.
dc.titleThe effect of bovine interferon-alpha I1 on pregnancy rate in heifers.
dc.typeOtro


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