In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis

dc.creatorBarral Netto, Manoel
dc.creatorVon Sohsten, R. L
dc.creatorTeixeira, M
dc.creatordosSantos, Washington Luis Conrado
dc.creatorPompeu, Margarida Maria de Lima
dc.creatorMoreira, R. A
dc.creatorOliveira, J. T
dc.creatorCavada, Benildo Sousa
dc.creatorFalcoff, E
dc.creatorBarral, Aldina Maria Prado
dc.date2014-03-26T16:41:14Z
dc.date2014-03-26T16:41:14Z
dc.date1996
dc.date.accessioned2023-09-26T20:38:34Z
dc.date.available2023-09-26T20:38:34Z
dc.identifierBARRAL-NETTO, M. et al. In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis. Acta Tropica, v. 60, n. 4, p. 237-250 237, 1996.
dc.identifier0001-706X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7452
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861180
dc.descriptionIn vivo administration of Canavalia brasiliensis lectin (at the time of infection, or maintained throughout the infection) reduced the lesions of highly susceptible BALB/c mice infected by Leishmania amazonensis. At the doses used C. brasiliensis lectin (ConBr) does not interfere with penetration or fate of Leishmania in the macrophages in vitro. Since Interferon-gamma (IFN-gamma) is the major macrophage activating factor, and considered a critical element in the successful immune response against leishmaniasis, we explored its participation in this phenomenon. ConBr either in vivo or in vitro induced IFN-gamma production in normal or in leishmania-infected BALB/c mice. However we were unable to change the course of disease by in vivo IFN-gamma administration (although IFN-gamma preparations were effective in inducing a leishmanicidal effect in vitro on L. amazonensis-infected peritoneal macrophages). Additionally, IFN-gamma neutralization with anti-IFN-gamma monoclonal antibody did not alter the protection conferred by ConBr administration. These data show that lectin administration in vivo is protective in the otherwise unchecked L. amazonensis infection of BALB/c mice, and suggest that such effect is not mediated by IFN-gamma.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Science B.V
dc.rightsopen access
dc.subjectLeishmaniasis
dc.subjectLeishmania
dc.subjectTegumentary leishmaniasis
dc.subjectExperimental leishmaniasis
dc.subjectCanavalia brasiliensis
dc.subjectInterferon-y
dc.subjectAnimais
dc.subjectFeminino
dc.subjectInterferon gama/biossíntese
dc.subjectLectinas/uso terapêutico
dc.subjectLeishmania mexicana
dc.subjectLeishmaniose Cutânea/terapia
dc.subjectInterferon gama/farmacocinética
dc.subjectLeishmaniose Cutânea/imunologia
dc.subjectLeishmaniose Cutânea/parasitologia
dc.subjectMacrófagos Peritoneais/efeitos de drogas
dc.subjectMacrófagos Peritoneais/parasitologia
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectRatos
dc.titleIn vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
dc.typeArticle


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