Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.

dc.creatorCarvalho Filho, Edgar Marcelino
dc.creatorBacellar, Maria Olívia Amado Ramos
dc.creatorPorto, Maria Aurélia da Fonseca
dc.creatorBraga, Silvane
dc.creatorCastro Filho, Bernardo Galvão
dc.creatorNeva, Franklin A
dc.date2014-08-07T13:02:14Z
dc.date2014-08-07T13:02:14Z
dc.date2001
dc.date.accessioned2023-09-26T20:38:16Z
dc.date.available2023-09-26T20:38:16Z
dc.identifierCARVALHO FILHO, E. M. et al. Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. Journal of Acquired Immune Deficiency Syndromes, v. 27, n. 1, p. 1-6, 2001.
dc.identifier1525-4135
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8148
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861075
dc.descriptionThe modulation of the immune response has been used as therapy for clinical disorders associated with human T-lymphotropic virus type 1 (HTLV-1) infection. In this study, the cytokine profile was evaluated in 26 asymptomatic HTLV-1 blood donors. Additionally, both the cell responsible for producing interferon-gamma (IFN-gamma) and the role of exogenous interleukin (IL)-10 in downregulating IFN-gamma production were studied. Cytokine levels were determined in supernatants of unstimulated lymphocyte cultures by enzyme-linked immunosorbent assay. The levels of IFN-gamma, tumor necrosis factor-alpha, IL-5, and IL-10 were higher in supernatants of the lymphocyte cultures taken from HTLV-1-infected donors than in those taken from healthy subjects. Although depletion of CD8+ T cells and natural killer cells did not affect IFN-gamma production, depletion of CD4+ T cells significantly decreased IFN-gamma production. Furthermore, at a concentration of 2 ng/ml, IL-10 had only a minimum effect on IFN-gamma production, although at high concentrations (100 ng/ml), IL-10 decreased IFN-gamma production by 50% in HTLV-1-infected individuals. These data indicate that both T helper 1 and T helper 2 cytokines are elevated in HTLV-1 infection and that IL-10 in high concentrations modulates IFN-gamma production in these patients.
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott Williams & Wilkins
dc.rightsopen access
dc.subjectCellular immunity in HTLV-1
dc.subjectCitokines in HTLV-1
dc.subjectHTLV-1
dc.subjectImmune response in HTLV-1
dc.subjectImmunomodulation in HTLV-1
dc.subjectDoadores de Sangue
dc.subjectCitocinas/biossíntese
dc.subjectInfecções por HTLV-I/imunologia
dc.subjectVírus 1 Linfotrópico T Humano/imunologia
dc.subjectAdulto
dc.subjectLinfócitos T CD4-Positivos/imunologia
dc.subjectFeminino
dc.subjectAnticorpos Anti-HTLV-I/sangue
dc.subjectHumanos
dc.subjectInterferon gama/biossíntese
dc.subjectCélulas Matadoras Naturais/imunologia
dc.subjectMasculino
dc.subjectMeia-Idade
dc.titleCytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.
dc.typeArticle


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