Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study

dc.creatorFerreira, Stephany Vasco
dc.creatorXavier, Flávia Caló Aquino
dc.creatorFreitas, Maria da Conceição Andrade de
dc.creatorNunes, Fábio Daumas
dc.creatorGurgel, Clarissa Araújo
dc.creatorCangussu, Maria Cristina Teixeira
dc.creatorMartins, Manoela Domingues
dc.creatorFreitas, Valéria Souza
dc.creatorSantos, Jean Nunes dos
dc.date2017-04-10T19:15:06Z
dc.date2017-04-10T19:15:06Z
dc.date2016
dc.date.accessioned2023-09-26T20:38:13Z
dc.date.available2023-09-26T20:38:13Z
dc.identifierFERREIRA, S. V. et al. Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study. Pathology – Research and Practice, v. 212, p. 761–766. 2016.
dc.identifier0344-0338
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18351
dc.identifier10.1016/j.prp.2016.05.007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861057
dc.descriptionCNPq
dc.descriptionIn view of the similarity of clinicopathological features between reactive lesions of the oral cavity, the objective of the present study was to investigate the density of MCs (mast cells) and microvessels in a series of these lesions. Thirty-seven cases of reactive lesions including fibrous hyperplasia (FH, n=10), inflammatory fibrous hyperplasia (IFH, n=10), peripheral giant cell lesion (PGCL, n=10) and lobular capillary hemangioma (LCH, n=7) were investigated using immunohistochemistry for mast cell tryptase and CD34. For comparative purposes, central giant cell lesions (CGCL, n=5) were included. A higher MC density was observed in LCH (37.01), while CGCL exhibited the lowest density (n=8.14). There was a significant difference in MC density when all reactive lesions were compared to CGCL (p=0.001). The largest mean density of microvessels was observed in LCH (n=21.69). The smallest number was observed in CGCL (n=6.24). There was a significant difference in microvessel density when the reactive lesions were compared to CGCL (p=0.003). There was a significant and direct correlation between the density of MCs and microvessels only for IFH (p=0.048) and CGCL (p=0.005). A significant and direct correlation between the mean density of MCs and microvessels was observed when the reactive lesions were analyzed as a whole (p=0.005). Our results suggest that mast cells contribute to the connective tissue framework and angiogenic function, as well as the development, of reactive lesions of the oral cavity, including FH, IFH, LCH and PGCL.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectMastócitos
dc.subjectAngiogênese
dc.subjectLesões orais reativas
dc.subjectMast cells
dc.subjectAngiogenesis
dc.subjectOral reactive lesions
dc.titleInvolvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study
dc.typeArticle


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