Cyclopia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research

dc.creatorOrioli, Iêda M.
dc.creatorAmar, Emmanuelle
dc.creatorBakker, Marian K.
dc.creatorBermejo-Sánchez, Eva
dc.creatorBianchi, Fabrizio
dc.creatorCanfield, Mark A.
dc.creatorClementi, Maurizio
dc.creatorCorrea, Adolfo
dc.creatorCsáky-Szunyogh, Melinda
dc.creatorFeldkamp, Marcia L.
dc.creatorLandau, Danielle
dc.creatorLeoncini, Emanuele
dc.creatorLi, Zhu
dc.creatorLowry, R. Brian
dc.creatorMastroiacovo, Pierpaolo
dc.creatorMorgan, Margery
dc.creatorMutchinick, Osvaldo M.
dc.creatorRissmann, Anke
dc.creatorRitvanen, Annukka
dc.creatorScarano, Gioacchino
dc.creatorSzabova, Elena
dc.creatorCastilla, Eduardo E.
dc.date2017-01-05T10:19:23Z
dc.date2017-01-05T10:19:23Z
dc.date2011
dc.date.accessioned2023-09-26T20:37:55Z
dc.date.available2023-09-26T20:37:55Z
dc.identifierORIOLI, Iêda M. et al. Cyclopia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research. Am J Med Genet C Semin Med Genet., v. 0, n.4, p.344–357, Nov. 2011.
dc.identifier1552-4868
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16718
dc.identifier1552-4876
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860955
dc.descriptionCyclopia is characterized by the presence of a single eye, with varying degrees of doubling of the intrinsic ocular structures, located in the middle of the face. It is the severest facial expression of the holoprosencephaly (HPE) spectrum. This study describes the prevalence, associated malformations, and maternal characteristics among cases with cyclopia. Data originated in 20 Clearinghouse (ICBDSR) affiliated birth defect surveillance systems, reported according to a single pre-established protocol. A total of 257 infants with cyclopia were identified. Overall prevalence was 1 in 100,000 births (95%CI: 0.89–1.14), with only one program being out of range. Across sites, there was no correlation between cyclopia prevalence and number of births (r = 0.08; P=0.75) or proportion of elective termination of pregnancy (r= −0.01; P=0.97). The higher prevalence of cyclopia among older mothers (older than 34) was not statistically significant. The majority of cases were liveborn (122/200; 61%) and females predominated (male/total: 42%). A substantial proportion of cyclopias (31%) were caused by chromosomal anomalies, mainly trisomy 13. Another 31% of the cases of cyclopias were associated with defects not typically related to HPE, with more hydrocephalus, heterotaxia defects, neural tube defects, and preaxial reduction defects than the chromosomal group, suggesting the presence of ciliopathies or other unrecognized syndromes. Cyclopia is a very rare defect without much variability in prevalence by geographic location. The heterogeneous etiology with a high prevalence of chromosomal abnormalities, and female predominance in HPE, were confirmed, but no effect of increased maternal age or association with twinning was observed.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectCyclopia (Planta)
dc.subjectHoloprosencefalia
dc.subjectPrevalência
dc.subjectTrissomia
dc.subjectEpidemiologia
dc.subjectcyclopia
dc.subjectholoprosencephaly
dc.subjecttrisomy 13
dc.subjectprevalence
dc.subjectglobal
dc.subjectworld prevalence
dc.subjectepidemiology
dc.subjectclincal
dc.titleCyclopia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research
dc.typeArticle


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