Extracellular vesicles in viral infections: two sides of the same coin?

dc.creatorMartins, Sharon de Toledo
dc.creatorAlves, Lysangela Ronalte
dc.date2021-01-08T19:32:14Z
dc.date2021-01-08T19:32:14Z
dc.date2020
dc.date.accessioned2023-09-26T20:37:42Z
dc.date.available2023-09-26T20:37:42Z
dc.identifierMARTINS, Sharon de Toledo et al. Extracellular vesicles in viral infections: two sides of the same coin? Frontiers in Cellular and Infection Microbiology, v.10, n. 593170, p. 1–14, 2020.
dc.identifier2235-2988
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45539
dc.identifier10.3389/fcimb.2020.593170
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860882
dc.descriptionExtracellular vesicles are small membrane structures containing proteins and nucleic acids that are gaining a lot of attention lately. They are produced by most cells and can be detected in several body fluids, having a huge potential in therapeutic and diagnostic approaches. EVs produced by infected cells usually have a molecular signature that is very distinct from healthy cells. For intracellular pathogens like viruses, EVs can have an even more complex function, since the viral biogenesis pathway can overlap with EV pathways in several ways, generating a continuum of particles, like naked virions, EVs containing infective viral genomes and quasi-enveloped viruses, besides the classical complete viral particles that are secreted to the extracellular space. Those particles can act in recipient cells in different ways. Besides being directly infective, they also can prime neighbor cells rendering them more susceptible to infection, block antiviral responses and deliver isolated viral molecules. On the other hand, they can trigger antiviral responses and cytokine secretion even in uninfected cells near the infection site, helping to fight the infection and protect other cells from the virus. This protective response can also backfire, when a massive inflammation facilitated by those EVs can be responsible for bad clinical outcomes. EVs can help or harm the antiviral response, and sometimes both mechanisms are observed in infections by the same virus. Since those pathways are intrinsically interlinked, understand the role of EVs during viral infections is crucial to comprehend viral mechanisms and respond better to emerging viral diseases.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectInfecções Virais
dc.subjectPartícula Viral
dc.subjectResposta Imune
dc.subjectVirus Infections
dc.subjectExtracellular Vesicles
dc.subjectHost-Pathogen Interactions
dc.subjectVirion
dc.subjectActive Immune Response
dc.subjectVirosis
dc.subjectVesículas Extracelulares
dc.subjectInteracciones Huésped-Patógeno
dc.subjectVirión
dc.subjectInmunidad Activa
dc.subjectMaladies virales
dc.subjectVésicules extracellulaires
dc.subjectInteractions hôte-pathogène
dc.subjectVirion
dc.subjectImmunité active
dc.subjectInfecções por Vírus
dc.subjectVesículas Extracelulares
dc.subjectInterações Hospedeiro-Patógeno
dc.subjectVírion
dc.subjectImunidade Ativa
dc.titleExtracellular vesicles in viral infections: two sides of the same coin?
dc.typeArticle


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