Epidemiological study of the association between anti-Lutzomyia longipalpis saliva antibodies and development of delayed-type hypersensitivity to Leishmania antigen

dc.creatorAquino, Dorlene Maria Cardoso de
dc.creatorCaldas, Arlene de Jesus Mendes
dc.creatorMiranda, José Carlos
dc.creatorSilva, Antonio Augusto Moura da
dc.creatorBarral Netto, Manoel
dc.creatorBarral, Aldina Maria Prado
dc.date2014-03-10T17:04:07Z
dc.date2014-03-10T17:04:07Z
dc.date2010
dc.date.accessioned2023-09-26T20:37:41Z
dc.date.available2023-09-26T20:37:41Z
dc.identifierAQUINO, D. M. C. et al. Epidemiological study of the association between anti-Lutzomyia longipalpis saliva antibodies and development of delayed-type hypersensitivity to Leishmania antigen. American Journal of Tropical Medicine and Hygiene, v.83, n. 4, p.825-827, 2010.
dc.identifier1476-1645
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7387
dc.identifier10.4269/ajtmh.2010.10-0182
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860875
dc.descriptionRecent reports from animal models and from cross-sectional studies have suggested that host responses to anti-Lutzomyia longipalpis saliva antibodies may be related to delayed-type hypersensitivity to Leishmania antigen. In a prospective cohort study, we evaluated 1,080 children from two endemic areas for visceral leishmaniasis (VL) by means of Kaplan-Meier analysis. The incidence rate of delayed-type hypersensitivity to Leishmania antigen, measured at the 24th follow-up month, was higher among those reactive to Lu. longipalpis saliva antibodies at the beginning of the study (0.0217 cases per person-month) than among those previously negative (0.0131 cases per person-month) (P value for the log-rank test = 0.0006). It seems that mounting an anti-saliva immune response helps the development of a cell-mediated anti-Leishmania response.
dc.formatapplication/pdf
dc.languageeng
dc.publisherThe American Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.subjectAnticorpos/sangue
dc.subjectAntígenos de Protozoários/imunologia
dc.subjectHipersensibilidade Tardia/etiologia
dc.subjectLeishmania/imunologia
dc.subjectLeishmaniose Visceral/diagnóstico
dc.subjectPsychodidae/imunologia
dc.subjectAnimais
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectEstudos de Coortes
dc.subjectHumanos
dc.subjectHipersensibilidade Tardia/imunologia
dc.subjectLactente
dc.subjectLeishmaniose Visceral/imunologia
dc.subjectRecém-Nascido
dc.titleEpidemiological study of the association between anti-Lutzomyia longipalpis saliva antibodies and development of delayed-type hypersensitivity to Leishmania antigen
dc.typeArticle


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