dc.creatorChaoui, Ana Karina Ferraz
dc.creatorAtta, Ajax Mercês
dc.creatorAtta, Maria Luiza Brito de Sousa
dc.creatorCastro Filho, Bernardo Galvão
dc.creatorSantiago, Mittermayer Barreto
dc.date2014-07-25T19:09:49Z
dc.date2014-07-25T19:09:49Z
dc.date2010
dc.date.accessioned2023-09-26T20:37:10Z
dc.date.available2023-09-26T20:37:10Z
dc.identifierFERRAZ-CHAOUI, A. K. et al. Study of autoantibodies in patients with keratoconjunctivitis sicca infected by the human T cell lymphotropic virus type 1. Rheumatology International, v. 30, n. 6, p. 775-778, 2010.
dc.identifier1437-160X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8085
dc.identifier10.1007/s00296-009-1066-5
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860695
dc.descriptionHuman T cell lymphotropic virus type 1 (HTLV-1) is endemic in many regions of the world, including Brazil, and has been associated to several immunological manifestations such as arthritis, uveitis, dermatitis and Sjögren’s syndrome. This study was intended to evaluate the frequency of autoantibodies in patients infected with HTLV-1 and manifesting keratoconjunctivitis sicca (KCS). HTLV-1 patients with KCS, enrolled in a reference ambulatory of the city of Salvador, were tested for autoantibodies such as antinuclear antibodies, rheumatoid factor, anti- SSA/Ro and anti-SSB/La. Two comparison groups were also included: (a) HTLV-1 patients without KCS and (b) seronegative patients with KCS. Correlation of proviral load (PVL) in HTLV-1 patients with presence or absence of KCS was also assessed. No autoantibodies were detected in HTLV-1 patients with KCS. The PVL of HTLV-1 patients was higher in patients with KCS without other clinical manifestations customarily associated to HTLV-1. In conclusion, in this study, no changes were observed in humoral immunity concerning production of certain autoantibodies in HTLV-1-infected patients with KCS, which suggests that other mechanisms may be involved in the pathogenesis of this manifestation. Additionally, PVL may be a marker of KCS development in these patients.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsopen access
dc.subjectHTLV-1
dc.subjectAutoantibodies
dc.subjectKeratoconjunctivitis sicca
dc.subjectProviral load
dc.subjectAutoanticorpos/sangue
dc.subjectInfecções por HTLV-I/complicações
dc.subjectCeratoconjuntivite Seca/imunologia
dc.subjectAdulto
dc.subjectIdoso
dc.subjectAnticorpos Antinucleares/análise
dc.subjectAnticorpos Antinucleares/sangue
dc.subjectAutoanticorpos/análise
dc.subjectMarcadores Biológicos/análise
dc.subjectBrasil
dc.subjectEstudo de Coortes
dc.subjectFeminino
dc.subjectHumanos
dc.subjectImunidade Humoral/fisiologia
dc.subjectCeratoconjuntivite Seca/sangue
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectProvirus/imunologia
dc.subjectFator Reumatoide/análise
dc.subjectRibonucleoproteínas/imunologia
dc.subjectCarga Viral
dc.titleStudy of autoantibodies in patients with keratoconjunctivitis sicca infected by the human T cell lymphotropic virus type 1.
dc.typeArticle


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