dc.creator | Chaoui, Ana Karina Ferraz | |
dc.creator | Atta, Ajax Mercês | |
dc.creator | Atta, Maria Luiza Brito de Sousa | |
dc.creator | Castro Filho, Bernardo Galvão | |
dc.creator | Santiago, Mittermayer Barreto | |
dc.date | 2014-07-25T19:09:49Z | |
dc.date | 2014-07-25T19:09:49Z | |
dc.date | 2010 | |
dc.date.accessioned | 2023-09-26T20:37:10Z | |
dc.date.available | 2023-09-26T20:37:10Z | |
dc.identifier | FERRAZ-CHAOUI, A. K. et al. Study of autoantibodies in patients with keratoconjunctivitis sicca infected by the human T cell lymphotropic virus type 1. Rheumatology International, v. 30, n. 6, p. 775-778, 2010. | |
dc.identifier | 1437-160X | |
dc.identifier | https://www.arca.fiocruz.br/handle/icict/8085 | |
dc.identifier | 10.1007/s00296-009-1066-5 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8860695 | |
dc.description | Human T cell lymphotropic virus type 1
(HTLV-1) is endemic in many regions of the world, including
Brazil, and has been associated to several immunological
manifestations such as arthritis, uveitis, dermatitis and
Sjögren’s syndrome. This study was intended to evaluate
the frequency of autoantibodies in patients infected with
HTLV-1 and manifesting keratoconjunctivitis sicca (KCS).
HTLV-1 patients with KCS, enrolled in a reference ambulatory
of the city of Salvador, were tested for autoantibodies
such as antinuclear antibodies, rheumatoid factor, anti-
SSA/Ro and anti-SSB/La. Two comparison groups were
also included: (a) HTLV-1 patients without KCS and (b)
seronegative patients with KCS. Correlation of proviral
load (PVL) in HTLV-1 patients with presence or absence of
KCS was also assessed. No autoantibodies were detected in
HTLV-1 patients with KCS. The PVL of HTLV-1 patients
was higher in patients with KCS without other clinical
manifestations customarily associated to HTLV-1. In conclusion,
in this study, no changes were observed in humoral
immunity concerning production of certain autoantibodies
in HTLV-1-infected patients with KCS, which suggests that
other mechanisms may be involved in the pathogenesis of
this manifestation. Additionally, PVL may be a marker of
KCS development in these patients. | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | Springer | |
dc.rights | open access | |
dc.subject | HTLV-1 | |
dc.subject | Autoantibodies | |
dc.subject | Keratoconjunctivitis sicca | |
dc.subject | Proviral load | |
dc.subject | Autoanticorpos/sangue | |
dc.subject | Infecções por HTLV-I/complicações | |
dc.subject | Ceratoconjuntivite Seca/imunologia | |
dc.subject | Adulto | |
dc.subject | Idoso | |
dc.subject | Anticorpos Antinucleares/análise | |
dc.subject | Anticorpos Antinucleares/sangue | |
dc.subject | Autoanticorpos/análise | |
dc.subject | Marcadores Biológicos/análise | |
dc.subject | Brasil | |
dc.subject | Estudo de Coortes | |
dc.subject | Feminino | |
dc.subject | Humanos | |
dc.subject | Imunidade Humoral/fisiologia | |
dc.subject | Ceratoconjuntivite Seca/sangue | |
dc.subject | Masculino | |
dc.subject | Meia-Idade | |
dc.subject | Provirus/imunologia | |
dc.subject | Fator Reumatoide/análise | |
dc.subject | Ribonucleoproteínas/imunologia | |
dc.subject | Carga Viral | |
dc.title | Study of autoantibodies in patients with keratoconjunctivitis sicca infected by the human T cell lymphotropic virus type 1. | |
dc.type | Article | |