Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.

dc.creatorAndrade, Bruno de Bezerril
dc.creatorSantos, Cristiane J. N
dc.creatorCamargo, Luis M
dc.creatorSouza Neto, Sebastião Martins
dc.creatorReis Filho, Antonio José Souza
dc.creatorClarêncio, Jorge
dc.creatorMendonça, Vitor Rosa Ramos de
dc.creatorLuz, Nívea Farias
dc.creatorCamargo, Erney P
dc.creatorBarral, Aldina Maria Prado
dc.creatorSilva, Antonio Augusto Moura da
dc.creatorBarral Netto, Manoel
dc.date2012-11-23T17:42:53Z
dc.date2012-11-23T17:42:53Z
dc.date2011
dc.date.accessioned2023-09-26T20:36:41Z
dc.date.available2023-09-26T20:36:41Z
dc.identifierANDRADE, B.B. et al. Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon. PLoS One, v. 6, n. 5, p. e19841, 2011.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5863
dc.identifier10.1371/journal.pone.0019841
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860554
dc.descriptionAreas that are endemic for malaria are also highly endemic for hepatitis B virus (HBV) infection. Nevertheless, it is unknown whether HBV infection modifies the clinical presentation of malaria. This study aimed to address this question. METHODOLOGY AND FINDINGS: An observational study of 636 individuals was performed in Rondônia, western Amazon, Brazil between 2006 and 2007. Active and passive case detections identified Plasmodium infection by field microscopy and nested Polymerase Chain Reaction (PCR). HBV infections were identified by serology and confirmed by real-time PCR. Epidemiological information and plasma cytokine profiles were studied. The data were analyzed using adjusted multinomial logistic regression. Plasmodium-infected individuals with active HBV infection were more likely to be asymptomatic (OR: 120.13, P<0.0001), present with lower levels of parasitemia and demonstrate a decreased inflammatory cytokine profile. Nevertheless, co-infected individuals presented higher HBV viremia. Plasmodium parasitemia inversely correlated with plasma HBV DNA levels (r = -0.6; P = 0.0003). CONCLUSION: HBV infection diminishes the intensity of malaria infection in individuals from this endemic area. This effect seems related to cytokine balance and control of inflammatory responses. These findings add important insights to the understanding of the factors affecting the clinical outcomes of malaria in endemic regions.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectHepatite B/epidemiologia
dc.subjectHepatite B/etiologia
dc.subjectMalária/complicações
dc.subjectPlasmodium falciparum/patogenicidade
dc.subjectPlasmodium vivax/patogenicidade
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectBrasil/epidemiologia
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectCitocinas/metabolismo
dc.subjectDNA Viral/genética
dc.subjectFeminino
dc.subjectHepatite B/diagnóstico
dc.subjectAnticorpos Anti-Hepatite B
dc.subjectAntígenos de Superfície da Hepatite B
dc.subjectVírus da Hepatite B/genética
dc.subjectHumanos
dc.subjectMalária/virologia
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectFatores de Risco
dc.subjectAdulto Jovem
dc.titleHepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
dc.typeArticle


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