Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke

dc.creatorBourhy, Lena
dc.creatorMazeraud, Aurélien
dc.creatorBozza, Fernando A.
dc.creatorTurc, Guillaume
dc.creatorLledo, Pierre-Marie
dc.creatorSharshar, Tarek
dc.date2022-06-27T23:34:05Z
dc.date2022-06-27T23:34:05Z
dc.date2022
dc.date.accessioned2023-09-26T20:36:30Z
dc.date.available2023-09-26T20:36:30Z
dc.identifierBOURHY, Lena et al. Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke. Frontiers in Immunology, v. 13, p. 1-10, 2022.
dc.identifier1664-3224
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53553
dc.identifier10.3389/fimmu.2022.834649
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860491
dc.descriptionDespite recent therapeutic advances, ischemic stroke is still a leading cause of death and disability. There is renewed attention on peripheral inflammatory signaling as a way of modulating the post-ischemic neuro-inflammatory process. The immune-brain crosstalk has long been the focus for understanding the mechanisms of sickness behavior, which is an adaptive autonomic, neuroendocrine, and behavioral response to a peripheral inflammation. It is mediated by humoral and neural pathways that mainly involve the circumventricular organs and vagal nerve, respectively. In this review we address the question of how sepsis and stroke can dysregulate this adaptive response, notably by impairing the central integration of peripheral signaling, but also by efferent control of the immune response. We highlight the potential role of gut-brain and brain-spleen signaling in stroke.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectImmune response
dc.subjectIschemic stroke
dc.subjectNeuromodulation
dc.subjectSepsis
dc.subjectSickness behavior
dc.titleNeuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke
dc.typeArticle


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