Killer immunoglobulin-like receptor (KIR) genes are associated with the risk of episodes of high-level and detectable viremia among HIV controllers [version 1; peer review: awaiting peer review]

dc.creatorSá, Nathalia Beatriz Ramos de
dc.creatorSilva, Karina dos S.
dc.creatorAlves, Marcelo Ribeiro
dc.creatorCaetano, Diogo Gama
dc.creatorCôrtes, Fernanda Heloise
dc.creatorAzevedo, Suwellen S. D. de
dc.creatorHoagland, Brenda
dc.creatorGrinsztejn, Beatriz
dc.creatorVeloso, Valdiléa G.
dc.creatorMorgado, Mariza G.
dc.creatorTeixeira, Sylvia Lopes Maia
dc.date2021-07-29T19:21:58Z
dc.date2021-07-29T19:21:58Z
dc.date2021
dc.date.accessioned2023-09-26T20:36:16Z
dc.date.available2023-09-26T20:36:16Z
dc.identifierSÁ, Nathalia Beatriz Ramos de et al. Killer immunoglobulin-like receptor (KIR) genes are associated with the risk of episodes of high-level and detectable viremia among HIV controllers [version 1; peer review: awaiting peer review]. FI000Research, v. 10, n. 546, 18 p, July 2021.
dc.identifier2046-1402
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48410
dc.identifier10.12688/f1000research.53683.1
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860424
dc.descriptionBackground: HIV controllers (HICs) constitute a heterogeneous group of HIV-1 individuals able to suppress plasma viremia to low or undetectable levels in the absence of antiretroviral therapy. Host genetic factors may be involved in the sustained control of viral replication observed. We investigated the distribution and the potential impact of human leukocyte antigens (HLA)-B and -C alleles, killer immunoglobulin-like receptor (KIR) genes, single nucleotide polymorphisms (SNPs) of the NLRP3, CARD8 and IL-1β inflammasome genes, and CCR5Δ32 mutation on the viral control among HICs.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectControladores de HIV
dc.subjectCarga viral
dc.subjectAntígeno CD52
dc.subjectInflamassomos
dc.subjectHIV controllers
dc.subjectViral load
dc.subjectHLA
dc.subjectKIR
dc.subjectCCR5 Δ32
dc.subjectInflammasome SNPs
dc.subjectAntígeno CD52
dc.subjectCanais de Potássio Corretores do Fluxo de Internalização
dc.titleKiller immunoglobulin-like receptor (KIR) genes are associated with the risk of episodes of high-level and detectable viremia among HIV controllers [version 1; peer review: awaiting peer review]
dc.typeArticle


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