Decrease in anti-Leishmania IgG3 and IgG1 after cutaneous leishmaniasis lesion healing is correlated with the time of clinical cure

dc.creatorSilva, G. A. Fagundes
dc.creatorGoncalves, R. Vieira
dc.creatorNepomuceno, M. P.
dc.creatorSouza, M. A. de
dc.creatorFavoreto, S.
dc.creatorOliveira Neto, M. P.
dc.creatorCruz, A. M. da
dc.creatorSilva, A. Gomes
dc.date2017-05-16T12:36:58Z
dc.date2017-05-16T12:36:58Z
dc.date2012
dc.date.accessioned2023-09-26T20:35:38Z
dc.date.available2023-09-26T20:35:38Z
dc.identifierSILVA, G. A. Fagundes et al. Decrease in anti-Leishmania IgG3 and IgG1 after cutaneous leishmaniasis lesion healing is correlated with the time of clinical cure. Parasite Immunology, v. 34, p. 486-491, 2012.
dc.identifier0141-9838
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18858
dc.identifier10.1111/j.1365-3024.2012.01379.x
dc.identifier1365-3024
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860220
dc.descriptionFor better efficiency in the establishment of American tegumentary leishmaniasis clinical cure, the World Health Organization suggests that the clinical criteria are supported by serologic data. The present study aims to investigate the dynamics of IgG subclass production in clinical evolution post-treatment of cutaneous leishmaniasis (CL). Paired sera from 23 subjects with CL resulting from Leishmania braziliensis infection were studied during the active lesion phase (aCL) and after clinical cure post-therapy (hCL), which included an alternative protocol with a low dose of antimony. Anti-Leishmania IgG and its subclasses were measured using ELISA, and the immunoglobulin levels were correlated with patients' clinical data. All of the subjects were clinically healed and did not present relapse during follow-up. Serum levels of anti-Leishmania IgG (r = -0·79; P < 0·0001), IgG1 (r = -0·64, P < 0·001) and IgG3 (r = -0·42, P < 0·045) in hCL were negatively correlated with the duration of clinical cure. After 24 months of clinical cure, 73% of samples were negative for IgG1 and 78% were negative for IgG3. In conclusion, the detection of serum anti-Leishmania IgG1 and IgG3 is an improved laboratory strategy to aid in the decision of interruption of the ambulatory follow-up of CL patients.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectCura clínica
dc.subjectLeishmaniose cutânea
dc.subjectEficácia terapêutica
dc.subjectBaixa dose de antimônio
dc.subjectLeishmania brasiliensis
dc.subjectEnsaio de Imunoadsorção Enzimática
dc.subjectClinical cure
dc.subjectCutaneous Leishmaniasis
dc.subjectELISA
dc.subjectIgG1
dc.subjectIgG3
dc.subjectLeishmania (Viannia) braziliensis
dc.subjectLow dose antimony
dc.subjectTherapeutic efficacy
dc.titleDecrease in anti-Leishmania IgG3 and IgG1 after cutaneous leishmaniasis lesion healing is correlated with the time of clinical cure
dc.typeArticle


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