Probiotic treatment during neonatal age provides optimal protection against experimental asthma through the modulation of microbiota and T cells

dc.creatorNunes, Caroline Fraga
dc.creatorNogueira, Jeane S.
dc.creatorVianna, Pedro Henrique Oliveira
dc.creatorCiambarella, Bianca Torres
dc.creatorRodrigues, Patrícia Machado
dc.creatorMiranda, Karla Rodrigues
dc.creatorLobo, Leandro Araújo
dc.creatorDomingues, Regina Maria Cavalcanti Pillotto
dc.creatorBusch, Mileane
dc.creatorAtella, Georgia Correa
dc.creatorVale, André Macedo
dc.creatorBellio, Maria
dc.creatorNóbrega, Alberto
dc.creatorCanto, Fábio B.
dc.creatorFucs, Rita
dc.date2018-10-05T21:02:32Z
dc.date2018-10-05T21:02:32Z
dc.date2018
dc.date.accessioned2023-09-26T20:35:27Z
dc.date.available2023-09-26T20:35:27Z
dc.identifierNUNES, Carolina Fraga; et al. Probiotic treatment during neonatal age provides optimal protection against experimental asthma through the modulation of microbiota and T cells. International Immunology, v. 30, n.4, p.155–169, 2018.
dc.identifier0953-8178
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29413
dc.identifier10.1093/intimm/dxy011
dc.identifier1460-2377
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860158
dc.descriptionThe incidence of allergic diseases, which increased to epidemic proportions in developed countries over the last few decades, has been correlated with altered gut microbiota colonization. Although probiotics may play a critical role in the restoration of gut homeostasis, their efficiency in the control of allergy is controversial. Here, we aimed to investigate the effects of probiotic treatment initiated at neonatal or adult ages on the suppression of experimental ovalbumin (OVA)-induced asthma. Neonatal or adult mice were orally treated with probiotic bacteria and subjected to OVA-induced allergy. Asthma-like symptoms, microbiota composition and frequencies of the total CD4+ T lymphocytes and CD4+Foxp3+ regulatory T (Treg) cells were evaluated in both groups. Probiotic administration to neonates, but not to adults, was necessary and sufficient for the absolute prevention of experimental allergen-induced sensitization. The neonatally acquired tolerance, transferrable to probiotic-untreated adult recipients by splenic cells from tolerant donors, was associated with modulation of gut bacterial composition, augmented levels of cecum butyrate and selective accumulation of Treg cells in the airways. Our findings reveal that a cross-talk between a healthy microbiota and qualitative features inherent to neonatal T cells, especially in the Treg cell subset, might support the beneficial effect of perinatal exposure to probiotic bacteria on the development of long-term tolerance to allergens.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsrestricted access
dc.subjectalergia
dc.subjecttolerância
dc.subjectimunorregulação
dc.subjectmicrobiota comensal
dc.subjectpulmão
dc.subjectallergy
dc.subjectcommensal microbiota
dc.subjectimmunoregulation
dc.subjecttolerance
dc.subjectlung
dc.titleProbiotic treatment during neonatal age provides optimal protection against experimental asthma through the modulation of microbiota and T cells
dc.typeArticle


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