Hyperplasia of elastic tissue in hepatic schistosomal fibrosis

dc.creatorAndrade, Zilton de Araújo
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.date2012-10-22T19:46:01Z
dc.date2012-10-22T19:46:01Z
dc.date1991
dc.date.accessioned2023-09-26T20:35:00Z
dc.date.available2023-09-26T20:35:00Z
dc.identifierANDRADE, Z. A.; FREITAS, L. A. Hyperplasia of elastic tissue in hepatic schistosomal fibrosis. Memórias do Instituto Oswaldo Cruz, v. 86, n. 4, p. 447-56, oct.-dec. 1991.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5710
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860001
dc.descriptionElastic tissue hyperplasia, revealed by means of histological, immunocytochemical and ultra-structural methods, appeared as a prominent change in surgical liver biopsies taken from 61 patients with schistosomal periportal and septal fibrosis. Such hyperplasia was absent in experimental murine schistosomiasis, including mice with "pipe-stem" fibrosis. Displaced connective tissue cells in periportal areas, such as smooth muscle cells, more frequently observed in human material, could be the site of excessive elastin synthesis, and could explain the differences observed in human and experimental materials. Elastic tissue, sometimes represented by its microfibrillar components, also appeared to be more condensed in areas of matrix (collagen) degradation, suggesting a participation of this tissue in the remodelling of the extracellular matrix. By its rectratile properties elastic tissue hyperplasia in hepatic schistosomiasis can cause vascular narrowing and thus play a role in the pathogenesis of portal hypertension.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectElastic tissue
dc.subjectElastin
dc.subjectSchistosomiasis
dc.subjectPeriportal fibrosis
dc.subjectLiver
dc.subjectTecido Elástico/patologia
dc.subjectCirrose Hepática/patologia
dc.subjectHepatopatias Parasitárias/patologia
dc.subjectEsquistossomose mansoni/patologia
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectFeminino
dc.subjectHumanos
dc.subjectHiperplasia/patologia
dc.subjectFígado/ultraestrutura
dc.subjectMasculino
dc.subjectMeia-Idade
dc.titleHyperplasia of elastic tissue in hepatic schistosomal fibrosis
dc.typeArticle


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