Haem oxygenase protects against thrombocytopaenia and malaria-associated lung injury

dc.creatorQuintanilha, Isaclaudia G. de Azevedo
dc.creatorMoraes, Isabel M. Medeiros de
dc.creatorFerreira, André C.
dc.creatorReis, Patrícia A.
dc.creatorAbreu, Adriana Vieira de
dc.creatorCampbell, Robert A.
dc.creatorWeyrich, Andrew S.
dc.creatorBozza, Patrícia T.
dc.creatorZimmerman, Guy A.
dc.creatorFaria Neto, Hugo C. Castro
dc.date2020-08-01T19:33:44Z
dc.date2020-08-01T19:33:44Z
dc.date2020
dc.date.accessioned2023-09-26T20:34:09Z
dc.date.available2023-09-26T20:34:09Z
dc.identifierQUINTANILHA, Isaclaudia G. de Azevedo et al. Haem oxygenase protects against thrombocytopaenia and malaria‑associated lung injury. Malaria Journal, v. 19, n. 234, p. 1-16, 2020.
dc.identifier1475-2875
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/42501
dc.identifier10.1186/s12936-020-03305-6
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8859711
dc.descriptionMalaria-triggered lung injury can occur in both severe and non-severe cases. Platelets may interact with parasitized erythrocytes, leukocytes and endothelium. These interactions can lead to microvessel obstructions and induce release of inflammatory mediators. Induction of the haem oxygenase enzyme is important in the host's response to free haem and to several other molecules generated by infectious or non-infectious diseases. In addition, an important role for the haem oxygenase-1 isotype has been demonstrated in experimental cerebral malaria and in clinical cases. Therefore, the present work aims to determine the influence of haem oxygenase in thrombocytopaenia and acute pulmonary injury during infection with Plasmodium berghei strain NK65.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMC
dc.rightsopen access
dc.subjectLesão pulmonar aguda
dc.subjectSíndrome do desconforto respiratório agudo
dc.subjectInflamação
dc.subjectMalária
dc.subjectPlaquetas
dc.subjectHeme oxygenase
dc.subjectAcute lung injury
dc.subjectAcute respiratory distress syndrome
dc.subjectInfammation
dc.subjectMalaria
dc.subjectPlatelets
dc.subjectHeme oxygenase
dc.subjectHeme Oxigenase (Desciclizante)
dc.titleHaem oxygenase protects against thrombocytopaenia and malaria-associated lung injury
dc.typeArticle


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