Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis

dc.creatorAraújo, Thessika Hialla Almeida
dc.creatorBarreto, Fernanda Khouri
dc.creatorMenezes, Aline Dórea Luz
dc.creatorLima, Clayton Pereira Silva de
dc.creatorOliveira, Rodrigo Santos de
dc.creatorLemos, Poliana da Silva
dc.creatorCastro Filho, Bernardo Galvão
dc.creatorKashima, Simone
dc.creatorFarre, Lourdes
dc.creatorBittencourt, Achilea Candida Lisboa
dc.creatorCarvalho, Edgar Marcelino de
dc.creatorSantos, Luciane Amorim
dc.creatorRego, Filipe Ferreira de Almeida
dc.creatorMiranda, Aline Cristina Andrade Mota
dc.creatorNunes, Márcio Roberto Teixeira
dc.creatorAlcântara, Luiz Carlos Júnior
dc.date2020-04-16T13:15:03Z
dc.date2020-04-16T13:15:03Z
dc.date2020
dc.date.accessioned2023-09-26T20:33:31Z
dc.date.available2023-09-26T20:33:31Z
dc.identifierARAÚJO, Thessika Hialla Almeida et al. Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis. Infection, Genetics and Evolution, p. 1-29, 2020.
dc.identifier1567-1348
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40798
dc.identifier10.1016/j.meegid.2019.104166
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8859494
dc.descriptionFAPESB and CNPq financial support.
dc.descriptionThe HTLV-1 is the first human retrovirus and is associated with several clinical syndromes, however, the pathogenesis of these clinical manifestations is still not fully understood. Furthermore, there are few complete genomes publicly available, about 0.12 complete genomes per 10,000 infected individuals and the databases have a major deficiency of sequences information. This study generated and characterized 31 HTLV-1 complete genomes sequences derived from individuals with Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM), Adult T-cell leukemia/lymphoma (ATL), infective dermatitis associated to HTLV-1 (IDH) and asymptomatic patients. These sequences are associated to clinical and epidemiological information about the patients. The sequencing data generated on Ion Torrent PGM platform were assembled and mapped against the reference HTLV-1 genome. These sequences were genotyped as Cosmopolitan subtype, Transcontinental subgroup. We identified the variants in the coding regions of the genome of the different clinical profiles, however, no statistical relation was detected. This study contributed to increase of HTLV-1 complete genomes in the world. Furthermore, to better investigate the contribution of HTLV-1 mutations for the disease outcome it is necessary to evaluate the interaction of the viral genome and characteristics of the human host.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectHTLV-1
dc.subjectGenoma
dc.subjectVariações de nucleotídeos
dc.subjectHTLV-1
dc.subjectComplete genome
dc.subjectNucleotide variations
dc.titleComplete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
dc.typePreprint


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