Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.

dc.creatorSouza, Márcia Maria de
dc.creatorSilva, L. M
dc.creatorBarbosa Junior, Aryon de Almeida
dc.creatorOliveira, Irismar Reis de
dc.creatorParaná, Raymundo
dc.creatorAndrade, Zilton de Araújo
dc.date2012-10-03T17:44:46Z
dc.date2012-10-03T17:44:46Z
dc.date2000
dc.date.accessioned2023-09-26T20:33:25Z
dc.date.available2023-09-26T20:33:25Z
dc.identifierSOUZA, M.M. de et al. Hepatic capillariasis in rats: a new model for testing antifibrotic drugs. Brazilian Journal of Medical Biological Research, v. 33, n. 11, p. 1329-34, nov. 2000.
dc.identifier0100-879X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5629
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8859455
dc.descriptionRats infected with the helminth Capillaria hepatica regularly develop septal hepatic fibrosis that may progress to cirrhosis in a relatively short time. Because of such characteristics, this experimental model was selected for testing drugs exhibiting antifibrosis potential, such as pentoxifylline, gadolinium chloride and vitamin A. Hepatic fibrosis was qualitatively and quantitatively evaluated in liver samples obtained by partial hepatectomy and at autopsy. The material was submitted to histological, biochemical and morphometric methods. A statistically significant reduction of fibrosis was obtained with pentoxifylline when administered intraperitoneally rather than intravenously. Gadolinium chloride showed moderate activity when administered prophylactically (before fibrosis had started), but showed a poor effect when fibrosis was well advanced. No modification of fibrosis was seen after vitamin A administration. Hydroxyproline content was correlated with morphometric measurements. The model appears to be adequate, since few animals die of the infection, fibrosis develops regularly in all animals, and the effects of different antifibrotic drugs and administration protocols can be easily detected.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectCapillaria hepatica
dc.subjectHepatic fibrosis
dc.subjectSeptal fibrosis
dc.subjectAntifibrotic drugs
dc.subjectInibidores da Agregação de Plaquetas/uso
dc.subjectVitamina A/uso terapêutico
dc.subjectInfecções por Enoplida/quimioterapia
dc.subjectGadolínio/uso terapêutico
dc.subjectCirrose Hepática/quimioterapia
dc.subjectPentoxifilina/uso terapêutico
dc.subjectAnimais
dc.subjectCapillaria
dc.subjectModelos Animais de Doenças
dc.subjectFeminino
dc.subjectCirrose Hepática/parasitologia
dc.subjectMasculino
dc.subjectRatos
dc.subjectRatos Wistar
dc.subjectFatores de Tempo
dc.titleHepatic capillariasis in rats: a new model for testing antifibrotic drugs.
dc.typeArticle


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