Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia

dc.creatorBurbelo, Peter D.
dc.creatorBrowne, Sarah K.
dc.creatorSampaio, Elizabeth P.
dc.creatorGiaccone, Giuseppe
dc.creatorZaman, Rifat
dc.creatorKristosturyan, Ervand
dc.creatorRajan, Arun
dc.creatorDing, Li
dc.creatorChing, Kathryn H.
dc.creatorBerman, Arlene
dc.creatorOliveira, Joao B.
dc.creatorHsu, Amy P.
dc.creatorKlimavicz, Caitlin M.
dc.creatorIadarola, Michael J.
dc.creatorHolland, Steven M.
dc.date2017-10-24T13:14:20Z
dc.date2017-10-24T13:14:20Z
dc.date2010
dc.date.accessioned2023-09-26T20:33:18Z
dc.date.available2023-09-26T20:33:18Z
dc.identifierBURBELO, Peter D. et al. Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia. Blood, v. 116, n. 29, p. 4848-4858, Dec. 2010.
dc.identifier0006-4971
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/22919
dc.identifier10.1182/blood-2010-05-286161
dc.identifier1528-0020
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8859414
dc.descriptionPatients with thymic malignancy have high rates of autoimmunity leading to a variety of autoimmune diseases, most commonly myasthenia gravis caused by anti-acetylcholine receptor autoantibodies. High rates of autoantibodies to cytokines have also been described, although prevalence, spectrum, and functionality of these anti-cytokine autoantibodies are poorly defined. To better understand the presence and function of anti-cytokine autoantibodies, we created a luciferase immunoprecipitation system panel to search for autoantibodies against 39 different cytokines and examined plasma from controls (n = 30) and patients with thymic neoplasia (n = 17). In this screen, our patients showed statistically elevated, but highly heterogeneous immunoreactivity against 16 of the 39 cytokines. Some patients showed autoantibodies to multiple cytokines. Functional testing proved that autoantibodies directed against interferon-α, interferon-β, interleukin-1α (IL-1α), IL-12p35, IL-12p40, and IL-17A had biologic blocking activity in vitro. All patients with opportunistic infection showed multiple anti-cytokine autoantibodies (range 3-11), suggesting that anti-cytokine autoantibodies may be important in the pathogenesis of opportunistic infections in patients with thymic malignancy. This study was registered at http://clinicaltrials.gov as NCT00001355.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Hematology
dc.rightsrestricted access
dc.subjectAnti-citocinas
dc.subjectAutoanticorpos
dc.subjectInfecção oportunista
dc.subjectNeoplasia tímica
dc.subjectAnti-cytokine autoantibodies
dc.subjectthymic neoplasia
dc.subjectopportunistic infection
dc.titleAnti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia
dc.typeArticle


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