Ageing Down-Modulates Liver Inflammatory Immune Responses to Schistosome Infection in Mice

dc.creatorFaria, Elaine Speziali de
dc.creatorAranha, Claudio Henrique Magalhães
dc.creatorCarvalho, Andréa Teixeira de
dc.creatorSantiago, Andrezza Fernanda
dc.creatorOliveira, Rafael Pires de
dc.creatorRezende, Michelle Carvalho de
dc.creatorCarneiro, Cláudia Martins
dc.creatorCorrêa, Deborah Aparecida Negrão
dc.creatorCoelho, Paulo Marcos Zach
dc.creatorFaria, Ana Maria Caetano de
dc.date2013-10-03T16:33:11Z
dc.date2013-10-03T16:33:11Z
dc.date2010
dc.date.accessioned2023-09-26T20:32:41Z
dc.date.available2023-09-26T20:32:41Z
dc.identifierFARIA, Elaine Speziali de et al. Ageing Down-Modulates Liver Inflammatory Immune Responses to Schistosome Infection in Mice. Scand J Immunol., v. 71, n. 4, p. 240-248, Apr. 2010.
dc.identifier0300-9475
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7079
dc.identifier10.1111/j.1365-3083.2010.02370.x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8859223
dc.descriptionAgeing is associated with several alterations in the immune system. Our aim in this study was to compare the development of immunity to Schistosoma mansoni infection in young versus aged C57Bl/6 mice using the liver as the main organ to evaluate pathological alterations and immune responses. In the acute phase, young mice had large liver granulomas with fibrosis and inflammatory cells. Chronic phase in young animals was associated with immunomodulation of granulomas that became reduced in size and cellular infiltrate. On the other hand, aged animals presented granulomas of smaller sizes already in the acute phase. Chronic infection in these mice was followed by no alteration in any of the inflammatory parameters in the liver. In concert with this finding, there was an increase in activated CD4+ T, CD19+ B and NK liver cells in young mice after infection whereas old mice had already higher frequencies of activated B, NK and CD4+ T liver cells and infection does not change these frequencies. After infection, liver production of inflammatory and regulatory cytokines such as IFN-gamma, IL-4 and IL-10 increased in young but not in old mice that had high levels of IL-4 and IL-10 regardless of their infection status. Our data suggest that the unspecific activation status of the immune system in aged mice impairs inflammatory as well as regulatory immune responses to S. mansoni infection in the liver, where major pathological alterations and immunity are at stage. This poor immune reactivity may have a beneficial impact on disease development.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBlackwell Scientific Publications
dc.rightsrestricted access
dc.subjectCytokines/immunology
dc.subjectFlow Cytometry
dc.subjectInflammation/immunology
dc.subjectInflammation/pathology
dc.subjectSchistosomiasis mansoni/immunologyy
dc.subjectSchistosomiasis mansoni/pathology
dc.titleAgeing Down-Modulates Liver Inflammatory Immune Responses to Schistosome Infection in Mice
dc.typeArticle


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