Mechanism of action of glycyrrhizin against Plasmodium falciparum

dc.creatorSoeiro, Maria de Nazare Correia
dc.creatorVergoten, Gérard
dc.creatorBailly, Christian
dc.date2021-09-02T14:54:57Z
dc.date2021-09-02T14:54:57Z
dc.date2021
dc.date.accessioned2023-09-26T20:32:23Z
dc.date.available2023-09-26T20:32:23Z
dc.identifierSOEIRO, Maria de Nazaré Correia; VERGOTEN, Gérard; BAILLY, Christian. Mechanism of action of glycyrrhizin against Plasmodium falciparum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210084, 7 p, 2021.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48916
dc.identifier10.1590/0074-02760210084
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8859118
dc.descriptionExtracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity: (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectMalária
dc.subjectPlasmodium
dc.subjectGlyoxalase 1
dc.subjectGlycyrrhizin
dc.subjectColesterol
dc.subjectCholesterol
dc.subjectGlycyrrhizin
dc.subjectGlyoxalase 1
dc.subjectHMGB1, Malaria
dc.subjectPlasmodium
dc.titleMechanism of action of glycyrrhizin against Plasmodium falciparum
dc.typeArticle


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