High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: a multicenter study

dc.creatorAlves, Arthur Daniel Rocha
dc.creatorLangella, Barbara Barbosa
dc.creatorBarbosa, Jakeline Ribeiro
dc.creatorLima, Danielle Malta
dc.creatorColares, Jeová Keny Baima
dc.creatorGarcia, Rita de Cassia Nasser Cubel
dc.creatorPinto, Marcelo Alves
dc.creatorVillar, Livia Melo
dc.creatorAmado, Luciane Almeida
dc.date2020-10-20T18:50:58Z
dc.date2020-10-20T18:50:58Z
dc.date2020
dc.date.accessioned2023-09-26T20:32:13Z
dc.date.available2023-09-26T20:32:13Z
dc.identifierALVES, Arthur Daniel Rocha et al. High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: a multicenter study. International Journal of Infectious Diseases, [Hamilton], v. 100, p. 350-356, 2020.
dc.identifier1201-9712
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44093
dc.identifier10.1016/j.ijid.2020.09.010
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8859056
dc.descriptionInstituto Oswaldo Cruz/ Fundação Oswaldo Cruz e Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
dc.descriptionObjectives: Parvovirus B19 (B19V) infection is commonly acute and self-limited, but in chronic kidney disease (CKD) patients under dialysis treatment, this infection could increase susceptibility to acute and chronic anemia. The aim of this study was to evaluate the frequency and risk of B19V infection among Brazilian CKD patients under dialysis. Methods: A study was conducted among 221 CKD patients and a control group of 142 blood donors. B19V infection was evaluated in serum samples by real-time PCR, and ELISA (anti-B19V IgM and IgG). Results: B19V DNA was detected in 65% (145/221) of CKD patients, which was significantly higher (p < 0.001) than in the blood donors (6.3%). Simultaneous detection of B19V IgG and viremia was shown in 40.3% of CKD patients, which was indicative of persistent B19V infection. CKD patients showed an increased risk of developing B19V infection (OR = 28.1, CI = 13.5–58.5, p = 0.001). Conclusions: Despite an absence of clinical signs of B19V infection, these data highlight the importance of B19V infection in this high-risk population, since a persistent B19V infection could become clinically significant after renal transplant. Moreover, the persistent viremia should be considered as a potential risk, mainly because of the contamination of dialysis equipment.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectParvovirus B19, Human
dc.subjectRenal Insufficiency, Chronic
dc.subjectRisk Factors
dc.subjectRenal Dialysis
dc.subjectChronic kidney disease
dc.subjectDialysis
dc.subjectParvovirus B19
dc.subjectPrevalence
dc.subjectRisk
dc.subjectParvovirus B19 Humano
dc.subjectInsuficiência Renal Crônica
dc.subjectFatores de Risco
dc.subjectDiálise Renal
dc.titleHigh prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: a multicenter study
dc.typeArticle


Este ítem pertenece a la siguiente institución