In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi

dc.creatorSilva, Cristiane França Da
dc.creatorJunqueira, Angela
dc.creatorLima, Marli Maria
dc.creatorRomanha, Alvaro José
dc.creatorSales Junior, Policarpo Ademar
dc.creatorStephens, Chad E.
dc.creatorSom, Phanneth
dc.creatorBoykin, David W.
dc.creatorSoeiro, Maria de Nazaré Correia
dc.date2014-10-21T17:16:20Z
dc.date2014-10-21T17:16:20Z
dc.date2011
dc.date.accessioned2023-09-26T20:32:05Z
dc.date.available2023-09-26T20:32:05Z
dc.identifierSILVA, Cristiane França da et al. In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi. Journal of antimicrobial chemotherapy, 66(6): 1295-1297.
dc.identifier0305-7453
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8644
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8859005
dc.descriptionOBJECTIVES: As part of a search for new therapeutic opportunities to treat chagasic patients, in vitro efficacy studies were performed to characterize the activity of five novel arylimidamides (AIAs) against Trypanosoma cruzi. METHODS: The trypanocidal effect against T. cruzi was evaluated by light microscopy through the determination of IC₅₀ values. Cytotoxicity was determined by MTT assays against mouse cardiomyocytes. RESULTS: Our data demonstrated the trypanocidal efficacy of these new compounds against bloodstream trypomastigotes and intracellular amastigotes, exhibiting IC₅₀ values ranging from 0.015 to 2.5 and 0.02 to0.2 μM, respectively. One of the compounds, DB745B, was also highly active against a broad panel of isolates, including those naturally resistant to benznidazole. DB745B showed higher in vitro efficacy than the reference drugs used to treat patients (benznidazole IC₅₀= 12.94 μM) and to prevent blood bank infection (gentian violet IC₅₀= 30.6 μM). CONCLUSIONS: AIAs represent promising new chemical entities against T. cruzi and are also potential trypanocidal agents to prevent transfusion-associated Chagas' disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAcademic Press.
dc.rightsopen access
dc.subjectTrypanosoma cruzi/drug effects
dc.subjectAntiprotozoal Agents/toxicity
dc.subjectCell Survival/drug effects
dc.subjectParasitic Sensitivity Tests
dc.titleIn vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi
dc.typeArticle


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