Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil

dc.creatordosSantos, Washington Luis Conrado
dc.creatorSweet, Glória Maria Maranhão
dc.creatorOliveira, Marilia Bahiense
dc.creatorRocha, Paulo Novis
dc.date2013-01-25T18:29:50Z
dc.date2013-01-25T18:29:50Z
dc.date2011
dc.date.accessioned2023-09-26T20:31:57Z
dc.date.available2023-09-26T20:31:57Z
dc.identifierDOS-SANTOS, W.L.C. et al. Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil. Memórias do Instituto Oswaldo Cruz, v. 106, n. 7, p. 901-904, nov. 2011.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6274
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858961
dc.descriptionDistinct patterns of glomerular lesions, including membranoproliferative glomerulonephritis and focal segmental glomerulosclerosis, are associated with infection by Schistosoma mansoni or Schistosoma japonicum. Evidence suggests that immune complex deposition is the main mechanism underlying the different forms of schistosomal glomerulonephritis and that immune complex deposition may be intensified by portal hypertension. The relationship between focal segmental glomerulosclerosis and schistosomiasis remains poorly understood. A clinicopathologic classification of schistosomal glomerulopathies was proposed in 1992 by the African Association of Nephrology. In Brazil, mass treatment with oral medications has led to a decrease in the occurrence of schistosomal glomerulopathy. In a survey of renal biopsies performed in Salvador, Brazil, from 2003-2009, only 24 (4 percent) patients were identified as positive for S. mansoni infection. Among these patients, only one had the hepatosplenic form of the disease. Focal segmental glomerulosclerosis was found in seven patients and membranoproliferative glomerulonephritis was found in four patients. Although retrospective studies on the prevalence of renal diseases based on kidney biopsies may be influenced by many patient selection biases, a change in the distribution of glomerulopathies associated with nephrotic syndrome was observed along with a decline in the occurrence of severe forms of schistosomiasis.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSchistosomiasis
dc.subjectSchistosoma mansoni
dc.subjectSchistosoma japonicum
dc.subjectMesangiocapillary glomerulonephritis
dc.subjectKidney diseases
dc.subjectFocal segmental glomerulosclerosis
dc.subjectGlomerulonefrite
dc.subjectMembranoproliferativa/parasitologia
dc.subjectGlomerulosclerose Segmentar e Focal/parasitologia
dc.subjectEsquistossomose Japônica/complicações
dc.subjectEsquistossomose mansoni/complicações
dc.subjectBiópsia
dc.subjectGlomerulonefrite Membranoproliferativa/imunologia
dc.subjectGlomerulonefrite Membranoproliferativa/patologia
dc.subjectGlomerulosclerose Segmentar e Focal/imunologia
dc.subjectGlomerulosclerose Segmentar e Focal/patologia
dc.subjectEsquistossomose Japônica/imunologia
dc.subjectEsquistossomose Japônica/patologia
dc.subjectEsquistossomose mansoni/imunologia
dc.subjectEsquistossomose mansoni/patologia
dc.subjectHumanos
dc.titleSchistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil
dc.typeArticle


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