dc.creatorPitta, Izabela Jardim Rodrigues
dc.creatorHacker, Mariana de Andrea Vilas-Boas
dc.creatorAndrade, Ligia Rocha
dc.creatorSpitz, Clarissa Neves
dc.creatorVital, Robson Teixeira
dc.creatorSales, Anna Maria
dc.creatorAntunes, Sergio Luiz Gomes
dc.creatorSarno, Euzenir Nunes
dc.creatorJardim, Marcia Rodrigues
dc.date2022-08-12T14:10:09Z
dc.date2022-08-12T14:10:09Z
dc.date2022
dc.date.accessioned2023-09-26T20:31:47Z
dc.date.available2023-09-26T20:31:47Z
dc.identifierPITTA, Izabela Jardim Rodrigues et al. Follow-up assessment of patients with Pure Neural Leprosy in a reference center in Rio de Janeiro—Brazil. PLoS Negl Trop Dis., v. 16, n. 1, e0010070, p. 1 - 10, Jan. 2022.
dc.identifier1935-2727
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/54624
dc.identifier10.1371/journal.pntd.0010070
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858895
dc.descriptionIntroduction Pure Neural Leprosy (PNL) is a rare clinical form of leprosy in which patients do not present with the classical skin lesions but have a high burden of the disability associated with the disease. Clinical characteristics and follow up of patients in PNL are still poorly described in the literature. Objective This paper aims to describe the clinical, electrophysiological and histopathological characteristics of PNL patients, as well as their evolution after multidrug therapy (MDT). Methods Fifty-two PNL patients were selected. Clinical, nerve conduction studies (NCS), histopathological and anti-PGL-1serology were evaluated. Patients were also assessed monthly during the MDT. At the end of the MDT, all of the patients had a new neurological examination and 44 were submitted to another NCS. Results Paresthesia was the complaint most frequently reported by patients, and in the neurological examination the most common pattern observed was impairment in sensory and motor examination and a mononeuropathy multiplex. Painful nerve enlargement, a classical symptom of leprosy neuropathy, was observed in a minority of patients and in the motor NCS axonal injuries, alone or in combination with demyelinating features, were the most commonly observed. 88% of the patients did not present any leprosy reaction during MDT. There was no statistically significant difference between the neurological examinations, nor the NCS pattern, performed before and after the MDT.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectAvaliação
dc.subjectPacientes
dc.subjectHanseníase Neural Pura
dc.subjectCentro de referência
dc.subjectRio de Janeiro—Brasil
dc.subjectFollow-up
dc.subjectPatients
dc.subjectPure Neural Leprosy
dc.subjectReference center
dc.subjectRio de Janeiro—Brazil
dc.titleFollow-up assessment of patients with Pure Neural Leprosy in a reference center in Rio de Janeiro—Brazil
dc.typeArticle


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