Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment

dc.creatorBiembengut, Ísis Venturi
dc.creatorSouza, Tatiana de Arruda Campos Brasil de
dc.date2020-04-23T19:13:03Z
dc.date2020-04-23T19:13:03Z
dc.date2020
dc.date.accessioned2023-09-26T20:31:37Z
dc.date.available2023-09-26T20:31:37Z
dc.identifierBIEMBENGUT, Ísis Venturi; SOUZA, Tatiana de Arruda Campos Brasil de. Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID19 treatment. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, p. 1-10, 17 Apr. 2020.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40946
dc.identifier10.1590/0074-02760200179
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858840
dc.descriptionSARS-CoV-2 infection depends on viral polyprotein processing, an event catalyzed by the main proteinase Mpro. The solution of the SARS-CoV-2 Mpro tridimensional structure in the last month allowed the investigation of potential inhibitors of viral replication. As objective, this work aims to provide first evidences of the applicability of commercial y approved drugs to treat COVID-19. As methods used in this research: We screened 4,334 compounds to found potential inhibitors of SARS-CoV-2 replication using an in silico approach. Thereby we have as findings that, The higher scores interactions include antiviral components and drugs classified as coagulation modifiers, ACE and dipeptidyl peptidase 4 inhibitors, antimigraine agents, antihistamine. And finally as main conclusions: Our result evidenced the potential use of coagulation modifiers in COVID-19 treatment due to the structural similarity of SARS-CoV main protease Mpro and human coagulation factors thrombin and Factor Xa.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectCoronavírus
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectStructure
dc.subjectLigand binding
dc.subjectIn silico approach
dc.subjectCOVID-19
dc.subjectSARS-CoV-2 Mpro
dc.subjectCoronavírus
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectInfecções por Coronavirus
dc.subjectProteínas de Transporte
dc.subjectSimulação por Computador
dc.subjectEstrutura Molecular
dc.titleCoagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment
dc.typePreprint


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