Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins

dc.creatorMartins, Darliane A.
dc.creatorBomfim Filho, Lucius F.
dc.creatorSilva, Cleiton M. da
dc.creatorFátima, Ângelo de
dc.creatorLouro, Sonia R. W.
dc.creatorBatista, Denise G. J.
dc.creatorSoeiro, Maria de Nazaré C.
dc.creatorCarvalho, João Ernesto de
dc.creatorTeixeira, Letícia R.
dc.date2017-02-21T17:26:39Z
dc.date2017-02-21T17:26:39Z
dc.date2016
dc.date.accessioned2023-09-26T20:31:27Z
dc.date.available2023-09-26T20:31:27Z
dc.identifierMARTINS, Darliane A. et al. Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins. Braz. Chem. Soc., v..28, n.1, p.87-97, Jan. 2017.
dc.identifier0103-5053
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/17879
dc.identifier10.5935/0103-5053.20160150
dc.identifier1678-4790
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858775
dc.descriptionCopper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino) phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInstituto de Química - UNICAMP
dc.rightsopen access
dc.subjectAlbuminas
dc.subjectBase de schiff
dc.subjectComplexos de cobre (II)
dc.subjectDNA
dc.subjectAtividade biológica
dc.subjectSchiff base
dc.subjectcopper(II) complexes
dc.subjectbiological activity
dc.subjectDNA
dc.subjectalbumin
dc.titleCopper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins
dc.typeArticle


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