Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil

dc.creatorNeira-Goulart, Milena
dc.creatorSá, Nathalia Beatriz Ramos de
dc.creatorRibeiro-Alves, Marcelo
dc.creatorPerazzo, Hugo
dc.creatorGeraldo, Kim Mattos
dc.creatorRibeiro, Maria Pia Diniz
dc.creatorCardoso, Sandra Wagner
dc.creatorGrinsztejn, Beatriz
dc.creatorVeloso, Valdiléa G.
dc.creatorGomes, Larissa Rodrigues
dc.creatorCazote, Andressa da Silva
dc.creatorAlmeida, Dalziza Victalina de
dc.creatorGiacoia-Gripp, Carmem Beatriz Wagner
dc.creatorCôrtes, Fernanda Heloise
dc.creatorMorgado, Mariza Gonçalves
dc.date2023-06-13T00:20:04Z
dc.date2023-06-13T00:20:04Z
dc.date2023
dc.date.accessioned2023-09-26T20:31:23Z
dc.date.available2023-09-26T20:31:23Z
dc.identifierNEIRA-GOULART, Milena et al. Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil. Gene, p. 1-11, May 2023.
dc.identifier0378-1119
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/58991
dc.identifier10.1016/j.gene.2023.147325
dc.identifier1879-0038
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858756
dc.descriptionSince January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
dc.descriptionThe study protocol was approved by the Ethics Committee of the National Institute of Infectology Evandro Chagas (INI)/Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil, under approval number CAAE: 32449420.4.1001.5262. All procedures were performed in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national).
dc.descriptionThe study was supported by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJ (Grant number SEI-260003/002689/2020; SEI- 260003/013002/2021 and SEI260003/019710/2022) and INOVA FIOCRUZ/Fundação Oswaldo Cruz (Grant number 48401996705881). Hugo Perazzo is recipient of FAPERJ (E-26/201.351/2021), Mariza Gonçalves Morgado is recipient of CNPQ (314064/2018-4) and FAPERJ (E-26/201.177/2021), and Beatriz Grinsztejn is recipient of CNPQ (305789/2019-8) and FAPERJ (E-26/202.915/2018). The funding agencies played no role in the design of the study, data collection, analysis, or interpretation, nor in writing the manuscript.
dc.descriptionCOVID-19 has a broad spectrum of clinical manifestations. We assessed the impact of single nucleotide polymorphisms (SNPs) of inflammasome genesas risk factors for progression toCOVID-19 critical outcomes, such as mechanical ventilation support (MVS) or death.The study included 451 hospitalized individuals followed up at the INI/FIOCRUZ, Rio de Janeiro, Brazil, from 06/2020 to 03/2021. SNPs genotyping was determined by Real-Time PCR. We analyzed risk factors for progression to MVS (n = 174[38.6 %]) or death (n = 175[38.8 %])as a result of COVID-19 by Cox proportional hazardmodels.Slower progression toMVSwas associated with allele G (aHR = 0.66;P = 0.005) or the genotype G/G (aHR = 0.391;P = 0.006) in the NLRP3 rs10754558 or the allele G (aHR = 0.309;P = 0.004) in the IL1βrs1143634, while C allele in the NLRP3 rs4612666 (aHR = 2.342;P = 0.006) or in the rs10754558 (aHR = 2.957;P = 0.005) were associated with faster progression to death. Slower progression to death was associated to allele G (aHR = 0.563;P = 0.006) or the genotype A/G (aHR = 0.537;P = 0.005) in the CARD8 rs6509365; the genotype A/C in the IFI16 rs1101996 (aHR = 0.569;P = 0.011); the genotype T/T (aHR = 0.394;P = 0.004) or allele T (aHR = 0.68;P = 0.006) in the NLRP3 rs4612666, and the genotype G/G (aHR = 0.326;P = 0.005) or allele G (aHR = 0,68;P = 0.014) in the NLRP3 rs10754558. Our results suggest that inflammasome genetic variations might influence the critical clinical course of COVID-19.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectCOVID-19
dc.subjectInflammasome single nucleotide polymorphisms (SNPs)
dc.subjectRisk factors
dc.titleInflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil
dc.typeArticle


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