Nutritional profile of newborns with microcephaly and factors associated with worse outcomes

dc.creatorSantos, Samira Fernandes Morais dos
dc.creatorSoares, Fernanda Valente Mendes
dc.creatorAbranches, Andrea Dunshee de
dc.creatorCosta, Ana Carolina Carioca da
dc.creatorGomes Junior, Saint Clair dos Santos
dc.creatorFonseca, Vania de Matos
dc.creatorMoreira, Maria Elisabeth Lopes
dc.date2021-01-07T14:41:18Z
dc.date2021-01-07T14:41:18Z
dc.date2019
dc.date.accessioned2023-09-26T20:31:10Z
dc.date.available2023-09-26T20:31:10Z
dc.identifierDos Santos SFM, Soares FVM, de Abranches AD, da Costa ACC, Gomes-Júnior SCDS, Fonseca VM, Moreira MEL. Nutritional profile of newborns with microcephaly and factors associated with worse outcomes. Clinics (Sao Paulo). 2019 Oct 21;74:e798. doi: 10.6061/clinics/2019/e798. PMID: 31644665; PMCID: PMC6791297.
dc.identifier1807-5932
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45526
dc.identifier10.6061/clinics/2019/e798
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858683
dc.descriptionObjective: To describe the nutritional profile of newborns with microcephaly and factors associated with worse outcomes during the first 14 days of life. Methods: This investigation is a longitudinal, descriptive study carried out in 21 full-term neonates exposed vertically to the Zika virus and hospitalized in a neonatal intensive care unit from February to September 2016. Patients receiving parenteral nutrition were excluded. Data analysis was performed using a generalized estimating equation model and Student's t-test to evaluate the association between worsening weight-for-age z-scores and independent clinical, sociodemographic and nutritional variables during hospitalization, with p<0.05 indicating significance. Results: During hospitalization, there was a decrease in the mean values of the weight-for-age z-scores. The factors associated with worse nutritional outcomes were symptomatic exposure to the Zika virus, low maternal schooling, absence of maternal income and consumption of infant formula (p<0.05). Calcification and severe microcephaly were also associated with poor nutritional outcomes. Energy and macronutrient consumption remained below the recommendations and had an upward trend during hospitalization. Conclusion: The presence of cerebral calcification, the severity of microcephaly and symptomatic maternal exposure to Zika virus affected the nutritional status of newborns. In terms of nutritional factors, human milk intake had a positive impact, reducing weight loss in the first days of life. Other known factors, such as income and maternal schooling, were still associated with a poor nutritional status.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFaculdade de Medicina - USP
dc.rightsopen access
dc.subjectAdolescent
dc.subjectAdult
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectLongitudinal Studies
dc.subjectMale
dc.subjectMicrocephaly / physiopathology
dc.subjectMicrocephaly / virology
dc.subjectNutritional Status / physiology
dc.subjectRisk Factors
dc.subjectSeverity of Illness Index
dc.subjectSocioeconomic Factors
dc.subjectYoung Adult
dc.subjectZika Virus Infection / complications
dc.subjectZika Virus
dc.subjectMicrocephaly
dc.subjectNutritional Status
dc.subjectNewborn
dc.titleNutritional profile of newborns with microcephaly and factors associated with worse outcomes
dc.typeArticle


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