Typical Neuron Guiding Molecules Constitutively Control Thymus Physiology

dc.creatorCruz, Daniella Arêas Mendes da
dc.creatorSavino, Wilson
dc.date2017-01-12T11:56:50Z
dc.date2017-01-12T11:56:50Z
dc.date2014
dc.date.accessioned2023-09-26T20:31:00Z
dc.date.available2023-09-26T20:31:00Z
dc.identifierCRUZ, Daniella Arêas Mendes da; SAVINO, Wilson. Typical Neuron Guiding Molecules Constitutively Control Thymus Physiology. Advances in Neuroimmune Biology, v.5, p.61-67, 2014.
dc.identifier1878-948X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16817
dc.identifier10.3233/NIB-140087
dc.identifier1878-9498
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858617
dc.descriptionCell migration is a crucial event for normal T cell development, and various ligand/receptor pairs have been indicated. Most of them, including chemokines and extracellular matrix proteins, have attractant properties upon thymocytes. Some other molecules can exert chemorepulsive effects, as we previously demonstrated for galectin-3. Nearly all these molecules are also expressed and can regulate the physiology of the nervous system. Conversely, some molecules initially described in the nervous system are also found in the immune system, notably in the thymus, suggesting their possible role as common mediators between neuroendocrine and immune systems. We summarize herein the data on the constitutive expression and role of typical neuron guiding molecules in the thymus. Furthermore, we discuss the complexity of thymocyte migration, which results from a network of molecular interactions, including those commonly found in the nervous system, and generate not only attraction, but also repulsion of migrating T cell precursors.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherIOS Press
dc.rightsrestricted access
dc.subjectTimo
dc.subjectInteracções Neuroimunes
dc.subjectMigração celular
dc.subjectNeuroimmune interactions
dc.subjectcell migration
dc.subjectthymus
dc.titleTypical Neuron Guiding Molecules Constitutively Control Thymus Physiology
dc.typeArticle


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