In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte

dc.creatorMeuser-Batista, Marcelo
dc.creatorVacani-Martins, Natalia
dc.creatorCascabulho, Cynthia Machado
dc.creatorBeghini, Daniela Gois
dc.creatorHenriques-Pons, Andrea
dc.date2020-08-18T20:25:15Z
dc.date2020-08-18T20:25:15Z
dc.date2020
dc.date.accessioned2023-09-26T20:30:57Z
dc.date.available2023-09-26T20:30:57Z
dc.identifierMeuser‐Batista, M, Vacani‐Martins, N, Cascabulho, CM, Beghini, DG, Henriques‐Pons, A. In the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte . J Leukoc Biol. 2020; 107: 695– 706. https://doi.org/10.1002/JLB.3A0220-399RR
dc.identifier0741-5400
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/42834
dc.identifier10.1002/JLB.3A0220-399RR
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858600
dc.descriptionIn secondary lymphoid organs, pathogen-derived and endogenous danger molecules are recognized by pattern recognition receptors, leading to adaptive proinflammatory immune responses. This conceptual rule does not apply directly to the liver, as hepatic immune cells tolerate gut-derived bacterial molecules from the flora. Therefore, the recognition of danger and proinflammatory stimuli differs between the periphery and the liver. However, the tolerant nature of the liver must be overcome in the case of infections or cancer, for example. The central paradigm is the basis for danger recognition and the balance between inflammation and tolerance in the liver. Here, we observed functional integration, with activated peripheral T lymphocytes playing a role in the induction of a proinflammatory environment in the liver in the presence of Trypanosoma cruzi antigens. When only parasite extract was orally administered, it led to the up-regulation of hepatic tolerance markers, but oral treatment plus adoptively transferred activated splenic T lymphocytes led to a proinflammatory response. Moreover, treated/recipient mice showed increased levels of TNF, IFN-γ, IL-6, and CCL2 in the liver and increased numbers of effector and/or effector memory T lymphocytes and F4/80+ cells. There was a reduction in FoxP3+ Treg cells, NKT cells, and γδ T lymphocytes with increased liver damage in the presence of activated peripheral T cells. Our results show that the induction of a proinflammatory liver response against T. cruzi danger molecules is at least partially dependent on cooperation with activated peripheral T cells.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociety for Leukocyte Biology [Society Publisher], Wiley [Commercial Publisher]
dc.rightsopen access
dc.subjectTrypanosoma. cruzi
dc.subjecthepatic T lymphocytes
dc.subjectliver immune response
dc.subjectperipheral T cells
dc.subjectpathogen‐associated molecular pattern (PAMP)
dc.subjecthepatic immunoregulation
dc.titleIn the presence of Trypanosoma cruzi antigens, activated peripheral T lymphocytes retained in the liver induce a proinflammatory phenotypic and functional shift in intrahepatic T lymphocyte
dc.typeArticle


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