Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug

dc.creatorLeandro, Katia Christina
dc.creatorMoreira, Josino Costa
dc.creatorFarias, Pércio Augusto Mardini
dc.date2016-04-26T11:58:24Z
dc.date2016-04-26T11:58:24Z
dc.date2013
dc.date.accessioned2023-09-26T20:30:54Z
dc.date.available2023-09-26T20:30:54Z
dc.identifierLEANDRO, K. C.; MOREIRA, J. C.; FARIAS, P. A. M. Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug. Am. J. Anal. Chem., v. 4, n. 6A, p. 47-51, 2013.
dc.identifier2156-8251
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/13968
dc.identifierhttp://dx.doi.org/10.4236/ajac.2013.46A007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858584
dc.descriptionLamivudine (also known as 3TC) is a dideoxynucleoside analogue, which undergoes intracellular phosphorylation in the putative active metabolite, lamivudine triphosphate. Lamivudine triphosphate prevents HIV replication by competitively inhibiting viral reverse transcriptase. Lamivudine has been extensively used in the treatment of HIV patients owing to its antiretroviral activity. For the determination of lamivudine in pharmaceuticals, an analytical methodology using voltammetry was developed. Lamivudine was reduced at a hanging mercury drop electrode (HMDE) at –1.16 V vs Ag/AgCl at pH 2.0. The influence of electroanalytical parameters such as scan rate (20 mV·s–1), amplitude (50 mV), nature of the support electrolyte (Clark-Lubs), and pH (2.0) on the voltammetric signal was optimized. Under these op- timized conditions, the method had been validated using pharmaceutical formulations. The lamivudine peak current varied linearly with its concentration from 1.15 to 10.40 mg·L–1, detection and determination limits of 0.46 and 1.0 mg·L–1, respectively, and recovery of 95.15% with a relative standard deviation of 1.10%.
dc.formatapplication/pdf
dc.languageeng
dc.publisherScientific Research Publishing
dc.rightsopen access
dc.subjectLamivudina
dc.subjectHIV
dc.subjectDrogas anti-retrovirais
dc.subjectVoltametria
dc.subjectLamivudine Determination
dc.subjectHIV
dc.subjectAntiretroviral Drugs
dc.subjectVoltammetric Analysis
dc.subjectLamivudina
dc.subjectFármacos Anti-HIV
dc.subjectInibidores da Transcriptase Reversa
dc.subjectHIV
dc.subjectAntirretrovirais
dc.titleDifferential pulse voltammetric studies on Lamivudine: an antiretroviral drug
dc.typeArticle


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