The Maze Pathway of Coevolution: A Critical Review over the Leishmania and Its Endosymbiotic History

dc.creatorCantanhêde, Lilian Motta
dc.creatorMata-Somarribas, Carlos
dc.creatorChourabi, Khaled
dc.creatorSilva, Gabriela Pereira da
dc.creatorChagas, Bruna Dias das
dc.creatorPereira, Luiza de Oliveira R.
dc.creatorBoité, Mariana Cortês
dc.creatorCupolillo, Elisa
dc.date2021-09-08T10:59:45Z
dc.date2021-09-08T10:59:45Z
dc.date2021
dc.date.accessioned2023-09-26T20:30:45Z
dc.date.available2023-09-26T20:30:45Z
dc.identifierCANTANHEDÊ, Lilian Motta et al. The Maze Pathway of Coevolution: A Critical Review over the Leishmania and Its Endosymbiotic History. Genes, v. 12, n. 657, 15 p, Apr. 2021.
dc.identifier2073-4425
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/49038
dc.identifier10.3390/genes12050657
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858521
dc.descriptionThe description of the genus Leishmania as the causative agent of leishmaniasis occurred in the modern age. However, evolutionary studies suggest that the origin of Leishmania can be traced back to the Mesozoic era. Subsequently, during its evolutionary process, it achieved worldwide dispersion predating the breakup of the Gondwana supercontinent. It is assumed that this parasite evolved from monoxenic Trypanosomatidae. Phylogenetic studies locate dixenous Leishmania in a well-supported clade, in the recently named subfamily Leishmaniinae, which also includes monoxe nous trypanosomatids. Virus-like particles have been reported in many species of this family. To date, several Leishmania species have been reported to be infected by Leishmania RNA virus (LRV) and Leishbunyavirus (LBV). Since the first descriptions of LRVs decades ago, differences in their genomic structures have been highlighted, leading to the designation of LRV1 in L. (Viannia) species and LRV2 in L. (Leishmania) species. There are strong indications that viruses that infect Leishmania spp. have the ability to enhance parasitic survival in humans as well as in experimental infections, through highly complex and specialized mechanisms. Phylogenetic analyses of these viruses have shown that their genomic differences correlate with the parasite species infected, suggesting a coevolutionary process. Herein, we will explore what has been described in the literature regarding the relationship between Leishmania and endosymbiotic Leishmania viruses and what is known about this association that could contribute to discussions about the worldwide dispersion of Leishmania.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectLeishmania
dc.subjectVírus Leishmania
dc.subjectFilogenia
dc.subjectCoevolução
dc.subjectVírus protozoários endossimbiontes
dc.subjectLeishmania
dc.subjectLeishmania viruses
dc.subjectPhylogeny
dc.subjectCoevolution
dc.subjectEndosymbiont protozoan viruses
dc.titleThe Maze Pathway of Coevolution: A Critical Review over the Leishmania and Its Endosymbiotic History
dc.typeArticle


Este ítem pertenece a la siguiente institución