Biomarkers for schistosomiasis: Towards an integrative view of the search for an effective diagnosis

dc.creatorMoraes, Vanessa Silva
dc.creatorFerreira, Jaqueline Maria Siqueira
dc.creatorCoelho, Paulo Marcos Zech
dc.creatorGrenfell, Rafaella Fortini Queiroz
dc.date2015-07-17T17:59:59Z
dc.date2015-07-17T17:59:59Z
dc.date2014
dc.date.accessioned2023-09-26T20:30:43Z
dc.date.available2023-09-26T20:30:43Z
dc.identifierMORAES, Vanessa Silva et al. Biomarkers for schistosomiasis: Towards an integrative view of the search for an effective diagnosis. Acta Trop., vol. 132, p. 75-79, 2014.
dc.identifier0001-706X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/11394
dc.identifier10.1016/j.actatropica.2013.12.024
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858515
dc.descriptionHuman schistosomiasis, caused mainly by Schistosoma mansoni, S. japonicum, and S. hematobium, remains a prevalent and serious parasitic disease worldwide. Although it is a debilitating disease, a lack of sensitive methods for the precise diagnosis of active infection cases is important to prevent morbidity. The optimization of new diagnostic approaches may be accomplished by the selection of specific markers. In that manner, markers can be satisfactorily used for detection of different phases of infection, as acute and chronic phases, pre-patent and post-patent phases and after chemotherapy, improving the efficiency of methods. For that purpose, proteomics and glycomics analyses have been performed in schistosomes, in particular S. mansoni, using powerful high-throughput methodologies. These investigations have not only chartered protein, o-glycan and n-glycan profiles across developmental stages within mammalian host, but are also leading to the characterization of features of the surface tegument, the eggshell and excretory-secretory proteomes of schistosomes.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Ltd.
dc.rightsrestricted access
dc.subjectAdult worm
dc.subjectBiomarkers
dc.subjectDiagnosis
dc.subjectEgg
dc.subjectSchistosomiasis mansoni
dc.subjectSchistossomula
dc.titleBiomarkers for schistosomiasis: Towards an integrative view of the search for an effective diagnosis
dc.typeArticle


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