Host cell lipid bodies triggered by Trypanosoma cruzi infection and enhanced by the uptake of apoptotic cells are associated with prostaglandin E₂ generation and increased parasite growth

dc.creatorD'Avila, Heloisa
dc.creatorLima, Célio G. Freire de
dc.creatorRoque, Natalia R.
dc.creatorTeixeira, Livia
dc.creatorBarja-Fidalgo, Christina
dc.creatorSilva, Adriana R.
dc.creatorMelo, Rossana C. N.
dc.creatorDosreis, George A.
dc.creatorFaria Neto, Hugo C. Castro
dc.creatorBozza, Patrícia T.
dc.date2018-11-18T13:57:52Z
dc.date2018-11-18T13:57:52Z
dc.date2011
dc.date.accessioned2023-09-26T20:30:29Z
dc.date.available2023-09-26T20:30:29Z
dc.identifierD`Avila, Heloisa; et al. Host Cell Lipid Bodies Triggered by Trypanosoma cruzi Infection and Enhanced by the Uptake of Apoptotic Cells Are Associated With Prostaglandin E2 Generation and Increased Parasite Growth. The Journal of Infectious Diseases, v.204, p.951–61, 2011.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/30073
dc.identifier10.1093/infdis/jir432
dc.identifier1537-6613
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858425
dc.descriptionLipid bodies (lipid droplets) are lipid-rich organelles with functions in cell metabolism and signaling. Here, we investigate the mechanisms of Trypanosoma cruzi-induced lipid body formation and their contributions to host-parasite interplay. We demonstrate that T. cruzi-induced lipid body formation in macrophages occurs in a Toll-like receptor 2-dependent mechanism and is potentiated by apoptotic cell uptake. Lipid body biogenesis and prostaglandin E₂ (PGE₂) production triggered by apoptotic cell uptake was largely dependent of α(v)β₃ and transforming growth factor-β signaling. T. cruzi-induced lipid bodies act as sites of increased PGE synthesis. Inhibition of lipid body biogenesis by the fatty acid synthase inhibitor C75 reversed the effects of apoptotic cells on lipid body formation, eicosanoid synthesis, and parasite replication. Our findings indicate that lipid bodies are highly regulated organelles during T. cruzi infection with roles in lipid mediator generation by macrophages and are potentially involved in T. cruzi-triggered escape mechanisms.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsrestricted access
dc.subjectCorpos lipídicos
dc.subjectcélulas hospedeiras
dc.subjectTrypanosoma cruzi
dc.subjectCélulas Apoptóticas
dc.subjectProstaglandina E2
dc.subjectCrescimento de Parasita Aumentado
dc.subjectTrypanosoma cruzi infection
dc.subjectLipid Bodies
dc.subjectApoptotic Cells
dc.subjectProstaglandin E2 Generation
dc.subjectincreased Parasite Growth
dc.titleHost cell lipid bodies triggered by Trypanosoma cruzi infection and enhanced by the uptake of apoptotic cells are associated with prostaglandin E₂ generation and increased parasite growth
dc.typeArticle


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