Simple, Low-Cost and Long-Lasting Film for Virus Inactivation Using Avian Coronavirus Model as Challeng

dc.creatorColnago, Luiz Alberto
dc.creatorTrevisol, Iara Maria
dc.creatorRech, Daiane Voss
dc.creatorForato, Lucimara Aparecida
dc.creatorMitre, Cirlei Igreja do Nascimento
dc.creatorLeite, José Paulo Gagliardi
dc.creatorGiglioti, Rodrigo
dc.creatorOkino, Cintia Hiromi
dc.date2020-09-11T20:25:22Z
dc.date2020-09-11T20:25:22Z
dc.date2020
dc.date.accessioned2023-09-26T20:30:25Z
dc.date.available2023-09-26T20:30:25Z
dc.identifierCOLNAGO, Luiz Alberto et al. Simple, Low-Cost and Long-Lasting Film for Virus Inactivation Using Avian Coronavirus Model as Challenge. International Journal of Environmental Research and Public Health. v. 17, n. 18, p. 1-9, Sept. 2020.
dc.identifier1661-7827
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/43340
dc.identifier10.3390/ijerph17186456
dc.identifier1660-4601
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858400
dc.descriptionThe COVID-19 infection, caused by SARS-CoV-2, is inequitably distributed and more lethal among populations with lower socioeconomic status. Direct contact with contaminated surfaces has been among the virus sources, as it remains infective up to days. Several disinfectants have been shown to inactivate SARS-CoV-2, but they rapidly evaporate, are flammable or toxic and may be scarce or inexistent for vulnerable populations. Therefore, we are proposing simple, easy to prepare, low-cost and efficient antiviral films, made with a widely available dishwashing detergent, which can be spread on hands and inanimate surfaces and is expected to maintain virucidal activity for longer periods than the current sanitizers. Avian coronavirus (ACoV) was used as model of the challenge to test the antivirus efficacy of the proposed films. Polystyrene petri dishes were covered with a thin layer of detergent formula. After drying, the films were exposed to different virus doses for 10 min and virus infectivity was determined using embryonated chicken eggs, and RNA virus quantification in allantoic fluids by RT-qPCR. The films inactivated the ACoV (ranging from 103.7 to 106.7 EID50), which is chemically and morphologically similar to SARS-CoV-2, and may constitute an excellent alternative to minimize the spread of COVID-19.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectCoronavírus
dc.subjectFilme
dc.subjectDetergente
dc.subjectAntiviral
dc.subjectVirucida
dc.subjectInativação
dc.subjectSanitização
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectCoronavirus
dc.subjectFilm
dc.subjectDetergent
dc.subjectAntiviral
dc.subjectVirucide
dc.subjectInactivation
dc.subjectSanitization
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.titleSimple, Low-Cost and Long-Lasting Film for Virus Inactivation Using Avian Coronavirus Model as Challeng
dc.typeArticle


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